Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases
O Weinreb, S Mandel, T Amit, MBH Youdim - The Journal of nutritional …, 2004 - Elsevier
Tea consumption is varying its status from a mere ancient beverage and a lifestyle habit, to a
nutrient endowed with possible prospective neurobiological–pharmacological actions …
nutrient endowed with possible prospective neurobiological–pharmacological actions …
Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (‐)‐epigallocatechin‐3‐gallate: implications for neurodegenerative diseases
S Mandel, O Weinreb, T Amit… - Journal of …, 2004 - Wiley Online Library
Accumulating evidence supports the hypothesis that brain iron misregulation and oxidative
stress (OS), resulting in reactive oxygen species (ROS) generation from H2O2 and …
stress (OS), resulting in reactive oxygen species (ROS) generation from H2O2 and …
Neuroprotection and neurorescue against Aβ toxicity and PKC‐dependent release of non‐amyloidogenic soluble precursor protein by green tea polyphenol (‐) …
Green tea extract and its main polyphenol constituent (‐)‐epigallocatechin‐3‐gallate
(EGCG) possess potent neuroprotective activity in cell culture and mice model of Parkinson's …
(EGCG) possess potent neuroprotective activity in cell culture and mice model of Parkinson's …
Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties
O Weinreb, T Amit, S Mandel, MBH Youdim - Genes & nutrition, 2009 - Springer
Tea, the major source of dietary flavonoids, particularly the epicatechins, signifies the
second most frequently consumed beverage worldwide, which varies its status from a simple …
second most frequently consumed beverage worldwide, which varies its status from a simple …
Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease.
RA Nixon, KI Saito, F Grynspan, WR Griffin… - Annals of the New …, 1994 - europepmc.org
Calpains (CANPs) are a family of calcium-dependent cysteine proteases under complex
cellular regulation. By making selective limited proteolytic cleavages, they activate or alter …
cellular regulation. By making selective limited proteolytic cleavages, they activate or alter …
[HTML][HTML] Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion
RM Nitsch, M Deng, JH Growdon… - Journal of Biological …, 1996 - Elsevier
Alzheimer's disease amyloid consists of amyloid β-peptides (Aβ) derived from the larger
precursor amyloid precursor protein (APP). Non-amyloidogenic APP processing involves …
precursor amyloid precursor protein (APP). Non-amyloidogenic APP processing involves …
The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling
S Roßner, U Ueberham, R Schliebs… - Progress in …, 1998 - Elsevier
The increased expression and/or abnormal processing of the amyloid precursor protein
(APP) is associated with the formation of amyloid plaques and cerebrovascular amyloid …
(APP) is associated with the formation of amyloid plaques and cerebrovascular amyloid …
Regulation of amyloid precursor protein cleavage
Multiple lines of evidence suggest that increased production and/or deposition of the β‐
amyloid peptide, derived from the amyloid precursor protein, contributes to Alzheimer's …
amyloid peptide, derived from the amyloid precursor protein, contributes to Alzheimer's …
Mechanisms of synaptic dysfunction in Alzheimer's disease
E Masliah - Histology and histopathology, 1995 - digitum.um.es
Alzheimer's disease (AD) is characterized by a progressive cognitive decline in which
memory, initiation, learning and conceptualization are severely affected. The main …
memory, initiation, learning and conceptualization are severely affected. The main …
Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease
Alzheimer's disease (AD) is a progressive senile dementia characterized by deposition of a
4 kDa peptide of 39–42 residues known as amyloid beta-peptide (Aβ) in the form of senile …
4 kDa peptide of 39–42 residues known as amyloid beta-peptide (Aβ) in the form of senile …