Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models
Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …
challenges facing cardiovascular medicine today. Despite being the most common form of …
Inflammation and fibrosis in murine models of heart failure
L Bacmeister, M Schwarzl, S Warnke, B Stoffers… - Basic research in …, 2019 - Springer
Heart failure is a consequence of various cardiovascular diseases and associated with poor
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …
Heart failure with preserved ejection fraction: from mechanisms to therapies
This review aims to provide a translational perspective on recent developments in heart
failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential …
failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential …
Heart failure with preserved ejection fraction in humans and mice: embracing clinical complexity in mouse models
Heart failure (HF) with preserved ejection fraction (HFpEF) is a multifactorial disease
accounting for a large and increasing proportion of all clinical HF presentations. As a clinical …
accounting for a large and increasing proportion of all clinical HF presentations. As a clinical …
Pre-clinical diastolic dysfunction
SH Wan, MW Vogel, HH Chen - Journal of the American College of …, 2014 - jacc.org
Pre-clinical diastolic dysfunction (PDD) has been broadly defined as left ventricular diastolic
dysfunction without the diagnosis of congestive heart failure (HF) and with normal systolic …
dysfunction without the diagnosis of congestive heart failure (HF) and with normal systolic …
Murine models of heart failure with preserved ejection fraction: a “fishing expedition”
Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …
Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol …
M Liao, Q Xie, Y Zhao, C Yang, C Lin, G Wang… - Pharmacological …, 2022 - Elsevier
Heart failure (HF), the main cause of death in patients with many cardiovascular diseases,
has been reported to be closely related to the complicated pathogenesis of autophagy …
has been reported to be closely related to the complicated pathogenesis of autophagy …
Role of inflammation in the pathogenesis of heart failure with preserved ejection fraction and its potential as a therapeutic target
Heart failure (HF) with preserved ejection fraction (HFPEF) is an increasingly prevalent
clinical syndrome with many unresolved issues regarding diagnosis, pathophysiology, and …
clinical syndrome with many unresolved issues regarding diagnosis, pathophysiology, and …
Clinical phenotypes in heart failure with preserved ejection fraction
Over the past 2 decades, the syndrome of heart failure with preserved ejection fraction
(HFpEF) received a lot of attention. 1–19 However, little therapeutic progress was made. 20 …
(HFpEF) received a lot of attention. 1–19 However, little therapeutic progress was made. 20 …
Cardiac fibroblasts support cardiac inflammation in heart failure
D Lindner, C Zietsch, J Tank, S Sossalla… - Basic research in …, 2014 - Springer
Cardiac remodeling and inflammation are hallmarks of cardiac failure and correlate with
outcome in patients. However, the basis for the development of both remains unclear. We …
outcome in patients. However, the basis for the development of both remains unclear. We …