Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder. It is caused
by loss-of-function mutations in the dystrophin gene. Currently, there is no cure. A highly …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

As we enter the new millennium, the prospects for the field of Biomedical Engineering are
bright. Individuals interested in pursuing careers in this field continue to increase and the …

Cytotoxic T lymphocytes (CTLs) specific for conserved viral antigens can respond to different
strains of virus, in contrast to antibodies, which are generally strain-specific. The generation …

The dystrophin-glycoprotein complex was tested for interaction with several components of
the extracellular matrix as well as actin. The 156-kD dystrophin-associated glycoprotein (156 …

The development of cell or gene therapies for diseases involving cells that are widely
distributed throughout the body has been severely hampered by the inability to achieve the …

Duchenne and Becker muscular dystrophies are caused by defects of the dystrophin gene.
Expression of this large X-linked gene is under elaborate transcriptional and splicing control …

Duchenne muscular dystrophy (DMD) is the most common and lethal genetic muscle
disorder, caused by recessive mutations in the dystrophin gene. One of every 3,500 males …

The concepts of gene therapy arose initially during the 1960s and early 1970s whilst the
development of genetically marked cells lines and the clarification of mechanisms of cell …

Plasmid pRSVL persisted and expressed luciferase for at least 19 months in mouse skeletal
muscle after intramuscular Injection. Other injected plasmids also stably expressed long …