As organisms evolve, the effects of mutations change as a result of epistatic interactions with
other mutations accumulated along the line of descent. This can lead to shifts in adaptability …

Predicting how new mutations alter phenotypes is difficult because mutational effects vary
across genotypes and environments. Recently discovered global epistasis, in which the …

Fitness effects of mutations throughout evolution | Nature Reviews Genetics Skip to main
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Mutations can alter the short-term fitness of an organism, as well as the rates and benefits of
future mutations. While numerous examples of these evolvability modifiers have been …

Epistasis is caused by genetic interactions among mutations that affect fitness. To
characterize properties and potential mechanisms of epistasis, we engineered eight double …

Population bottlenecks can impact the rate of adaptation in evolving populations. On the one
hand, each bottleneck reduces the genetic variation that fuels adaptation. On the other hand …

The tempo and mode of adaptation depends on the availability of beneficial alleles. Genetic
interactions arising from gene networks can restrict this availability. However, the extent to …

A major obstacle to predictive understanding of evolution stems from the complexity of
biological systems, which prevents detailed characterization of key evolutionary properties …

Pooled sequencing-based fitness assays are a powerful and widely used approach to
quantifying fitness of thousands of genetic variants in parallel. Despite the throughput of …

Domesticated strains of Saccharomyces cerevisiae have adapted to resist copper and
sulfite, two chemical stressors commonly used in winemaking. S. paradoxus has not …