Decades of research have mapped out the basic mechanics of the Hippo pathway. The
paralogues Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding …

Simple Summary Growth factors are hormone-like molecules able to promote division and
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …

The nuclear factor kappa B (NF-êB) family of transcription factors plays an essential role as
stressors in the cellular environment, and controls the expression of important regulatory …

The hippo signaling pathway is a highly conserved evolutionary signaling pathway that
plays an important role in regulating cell proliferation, organ size, tissue development, and …

Simple Summary YAP/TAZ are the central effectors of the Hippo pathway and orchestrate
their oncogenic program by binding to TEAD transcriptional factors. Here, we document a …

Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is currently the
standard first-line therapy for EGFR-mutated advanced non-small cell lung cancer (NSCLC) …

Ras proteins are essential mediators of a multitude of cellular processes, and its
deregulation is frequently associated with cancer appearance, progression, and metastasis …

Triple-negative breast cancer (TNBC) cells have not been usefully classified, and no
targeted therapeutic plans are currently available, resulting in a high recurrence rate and …

Prospective tumor pH-responsive and charge-convertible nanoparticles have been utilized
to reduce side effects and improve the active tumor-targeting ability and nuclear/cytoplasmic …

Osteosarcoma is a highly mortal bone tumor, with a high metastatic potential, promoted in
part by the enzyme procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (PLOD2). Increasing …