Repressive Chromatin in Caenorhabditis elegans: Establishment, Composition, and Function
J Ahringer, SM Gasser - Genetics, 2018 - academic.oup.com
Chromatin is organized and compacted in the nucleus through the association of histones
and other proteins, which together control genomic activity. Two broad types of chromatin …
and other proteins, which together control genomic activity. Two broad types of chromatin …
MORC protein family-related signature within human disease and cancer
H Wang, L Zhang, Q Luo, J Liu, G Wang - Cell death & disease, 2021 - nature.com
The microrchidia (MORC) family of proteins is a highly conserved nuclear protein
superfamily, whose members contain common domain structures (GHKL-ATPase, CW-type …
superfamily, whose members contain common domain structures (GHKL-ATPase, CW-type …
A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment
Toxoplasma gondii has a complex life cycle that is typified by asexual development that
takes place in vertebrates, and sexual reproduction, which occurs exclusively in felids and is …
takes place in vertebrates, and sexual reproduction, which occurs exclusively in felids and is …
The full-length transcriptome of C. elegans using direct RNA sequencing
NP Roach, N Sadowski, AF Alessi, W Timp… - Genome …, 2020 - genome.cshlp.org
Current transcriptome annotations have largely relied on short read lengths intrinsic to the
most widely used high-throughput cDNA sequencing technologies. For example, in the …
most widely used high-throughput cDNA sequencing technologies. For example, in the …
Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation
The Microrchidia (MORC) family of ATPases are required for transposable element (TE)
silencing and heterochromatin condensation in plants and animals, and C. elegans MORC …
silencing and heterochromatin condensation in plants and animals, and C. elegans MORC …
Genome‐wide association and environmental suppression of the mortal germline phenotype of wild C. elegans
The animal germline lineage needs to be maintained along generations. However, some
Caenorhabditis elegans wild isolates display a mortal germline phenotype, leading to …
Caenorhabditis elegans wild isolates display a mortal germline phenotype, leading to …
Single-nucleus RNA-seq reveals that MBD5, MBD6, and SILENZIO maintain silencing in the vegetative cell of developing pollen
Silencing of transposable elements (TEs) drives the evolution of numerous redundant
mechanisms of transcriptional regulation. Arabidopsis MBD5, MBD6, and SILENZIO act as …
mechanisms of transcriptional regulation. Arabidopsis MBD5, MBD6, and SILENZIO act as …
A cytoplasmic Argonaute protein promotes the inheritance of RNAi
RNAi-elicited gene silencing is heritable and can persist for multiple generations after its
initial induction in C. elegans. However, the mechanism by which parental-acquired trait …
initial induction in C. elegans. However, the mechanism by which parental-acquired trait …
Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms
CH Douse, S Bloor, Y Liu, M Shamin… - Nature …, 2018 - nature.com
Missense mutations in MORC2 cause neuropathies including spinal muscular atrophy and
Charcot–Marie–Tooth disease. We recently identified MORC2 as an effector of epigenetic …
Charcot–Marie–Tooth disease. We recently identified MORC2 as an effector of epigenetic …
Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3
Nuclear RNAi provides a highly tractable system to study RNA-mediated chromatin changes
and epigenetic inheritance. Recent studies have indicated that the regulation and function of …
and epigenetic inheritance. Recent studies have indicated that the regulation and function of …