Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

Fatty acid and fat synthesis in the liver is a highly regulated metabolic pathway that is
important for very low-density lipoprotein (VLDL) production and thus energy distribution to …

Hepatic de novo lipogenesis (DNL) is the biochemical process of synthesising fatty acids
from acetyl‐CoA subunits that are produced from a number of different pathways within the …

Increased fructose consumption has been suggested to contribute to non-alcoholic fatty liver
disease (NAFLD), dyslipidemia, and insulin resistance, but a causal role of fructose in these …

Transcription factor networks have evolved in order to control, coordinate, and separate, the
functions of distinct network modules spatially and temporally. In this review we focus on the …

Excessive sugar consumption and defective glucose sensing by hepatocytes contribute to
the development of metabolic diseases including type 2 diabetes mellitus (T2DM) and …

With the identification of ChREBP in 2001, our interest in understanding the molecular
control of carbohydrate sensing has surged. While ChREBP was initially studied as a master …

Carbohydrate response element-binding protein (ChREBP) plays an important role in the
development of type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease, as well …

Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in
which the liver appears to be selectively insulin resistant. Specifically, insulin fails to …