Mechanisms of adhesion G protein–coupled receptor activation

A Vizurraga, R Adhikari, J Yeung, M Yu… - Journal of Biological …, 2020 - ASBMB
Adhesion G protein–coupled receptors (AGPCRs) are a thirty-three-member subfamily of
Class B GPCRs that control a wide array of physiological processes and are implicated in …

Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology

T Lala, RA Hall - Physiological Reviews, 2022 - journals.physiology.org
Adhesion G protein-coupled receptors: structure, signaling, physiology, and
pathophysiology Page 1 REVIEW ARTICLE ADHESION G PROTEIN-COUPLED …

Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins

R Sando, X Jiang, TC Südhof - Science, 2019 - science.org
INTRODUCTION In the brain, synaptic connections form neuronal communication networks,
thereby constructing neural circuits. Synaptic connections are exquisitely specific and …

GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force

J Yeung, R Adili, EN Stringham, R Luo… - Proceedings of the …, 2020 - National Acad Sciences
Circulating platelets roll along exposed collagen at vessel injury sites and respond with
filipodia protrusion, shape change, and surface area expansion to facilitate platelet …

Adhesion G protein-coupled receptors: opportunities for drug discovery

F Bassilana, M Nash, MG Ludwig - Nature reviews Drug discovery, 2019 - nature.com
Adhesion G protein-coupled receptors (aGPCRs)—one of the five main families in the GPCR
superfamily—have several atypical characteristics, including large, multi-domain N termini …

Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function

SP Kordon, K Cechova, SJ Bandekar, K Leon… - Nature …, 2024 - nature.com
Abstract Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion
molecules involved in numerous physiological functions. aGPCRs have large multi-domain …

The adhesion GPCRs CELSR1–3 and LPHN3 engage G proteins via distinct activation mechanisms

DLH Bui, A Roach, J Li, SJ Bandekar, E Orput… - Cell reports, 2023 - cell.com
Adhesion G protein-coupled receptors (aGPCRs) are a large GPCR class that direct diverse
fundamental biological processes. One prominent mechanism for aGPCR agonism involves …

[HTML][HTML] The role of GPR56/ADGRG1 in health and disease

AK Singh, HH Lin - Biomedical journal, 2021 - Elsevier
GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the
physiological functions of the central and peripheral nervous systems, reproductive system …

Structural basis for adhesion G protein-coupled receptor Gpr126 function

K Leon, RL Cunningham, JA Riback, E Feldman… - Nature …, 2020 - nature.com
Many drugs target the extracellular regions (ECRs) of cell-surface receptors. The large and
alternatively-spliced ECRs of adhesion G protein-coupled receptors (aGPCRs) have key …

Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain

G Beliu, S Altrichter, R Guixà-González, M Hemberger… - Molecular cell, 2021 - cell.com
Adhesion G protein-coupled receptors (aGPCRs)/family B2 GPCRs execute critical tasks
during development and the operation of organs, and their genetic lesions are associated …