Mechanisms of adhesion G protein–coupled receptor activation
Adhesion G protein–coupled receptors (AGPCRs) are a thirty-three-member subfamily of
Class B GPCRs that control a wide array of physiological processes and are implicated in …
Class B GPCRs that control a wide array of physiological processes and are implicated in …
Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology
T Lala, RA Hall - Physiological Reviews, 2022 - journals.physiology.org
Adhesion G protein-coupled receptors: structure, signaling, physiology, and
pathophysiology Page 1 REVIEW ARTICLE ADHESION G PROTEIN-COUPLED …
pathophysiology Page 1 REVIEW ARTICLE ADHESION G PROTEIN-COUPLED …
Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins
INTRODUCTION In the brain, synaptic connections form neuronal communication networks,
thereby constructing neural circuits. Synaptic connections are exquisitely specific and …
thereby constructing neural circuits. Synaptic connections are exquisitely specific and …
GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force
Circulating platelets roll along exposed collagen at vessel injury sites and respond with
filipodia protrusion, shape change, and surface area expansion to facilitate platelet …
filipodia protrusion, shape change, and surface area expansion to facilitate platelet …
Adhesion G protein-coupled receptors: opportunities for drug discovery
F Bassilana, M Nash, MG Ludwig - Nature reviews Drug discovery, 2019 - nature.com
Adhesion G protein-coupled receptors (aGPCRs)—one of the five main families in the GPCR
superfamily—have several atypical characteristics, including large, multi-domain N termini …
superfamily—have several atypical characteristics, including large, multi-domain N termini …
Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function
SP Kordon, K Cechova, SJ Bandekar, K Leon… - Nature …, 2024 - nature.com
Abstract Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion
molecules involved in numerous physiological functions. aGPCRs have large multi-domain …
molecules involved in numerous physiological functions. aGPCRs have large multi-domain …
The adhesion GPCRs CELSR1–3 and LPHN3 engage G proteins via distinct activation mechanisms
DLH Bui, A Roach, J Li, SJ Bandekar, E Orput… - Cell reports, 2023 - cell.com
Adhesion G protein-coupled receptors (aGPCRs) are a large GPCR class that direct diverse
fundamental biological processes. One prominent mechanism for aGPCR agonism involves …
fundamental biological processes. One prominent mechanism for aGPCR agonism involves …
[HTML][HTML] The role of GPR56/ADGRG1 in health and disease
AK Singh, HH Lin - Biomedical journal, 2021 - Elsevier
GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the
physiological functions of the central and peripheral nervous systems, reproductive system …
physiological functions of the central and peripheral nervous systems, reproductive system …
Structural basis for adhesion G protein-coupled receptor Gpr126 function
K Leon, RL Cunningham, JA Riback, E Feldman… - Nature …, 2020 - nature.com
Many drugs target the extracellular regions (ECRs) of cell-surface receptors. The large and
alternatively-spliced ECRs of adhesion G protein-coupled receptors (aGPCRs) have key …
alternatively-spliced ECRs of adhesion G protein-coupled receptors (aGPCRs) have key …
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain
G Beliu, S Altrichter, R Guixà-González, M Hemberger… - Molecular cell, 2021 - cell.com
Adhesion G protein-coupled receptors (aGPCRs)/family B2 GPCRs execute critical tasks
during development and the operation of organs, and their genetic lesions are associated …
during development and the operation of organs, and their genetic lesions are associated …