The activities of daily living typically occur at metabolic rates below the maximum rate of
aerobic energy production. Such activity is characteristic of the nonsteady state, where …

The control theory of Kacser and Burns [in: Rate Control of Biological Processes (Davies,
DD ed) pp. 65–104, Cambridge University Press, London, 1973] and Heinrich and Rapoport …

Despite its crucial importance, scientists interested in the limitations of human physical
performance have only just started to give the field of oxygen uptake kinetics the attention it …

Suspensions of cultured C 1300 neuroblastoma cells, sarcoma 180 ascites tumor cells, and
Tetrahymena pyriformis cells were used to study the oxygen dependence of cellular energy …

One of the major features of an effectively functioning physiological system is its ability to
respond to a particular stressor with rapid response characteristics. For example, during …

To explore how mitochondria can respire at high physiological, extramitochondrial
phosphorylation potentials, two series of experiments were conducted. In the first, intact rat …

Publisher Summary This chapter discusses the control of oxidative metabolism by
adenosine diphosphate (ADP) availability in isolated mitochondria and perfused organs. It …

The model of Wilson and co-workers (2., 3., Arch. Biochem. Biophys. 182, 749–762) for the
regulation of mitochondrial oxidative phosphorylation has been extended to include the …

1 The digitonin fractionation procedure [Zuurendonk, PF and Tager, JM (1974) Biochim.
Biophys. Acta, 333, 393–399] was used to determine the concentrations of adenine …

An investigation into the measurement of Pi and ADP in rat liver in vivo and in freeze-
clamped extracts by 31P-nmr spectroscopy was carried out. The concentration of Pi …