Aberrant Notch signaling profoundly affects cancer progression. Especially the Notch3
receptor was found to be dysregulated in cancer, where its expression is correlated with …

Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The
expression and function of the membrane-type matrix metalloproteinase MMP14 is closely …

Plasma low-density lipoprotein (LDL) is primarily cleared by LDL receptor (LDLR). LDLR
can be proteolytically cleaved to release its soluble ectodomain (sLDLR) into extracellular …

Cancer cells exist in a complex ecosystem with numerous other cell types in the tumor
microenvironment (TME). The composition of this tumor/TME ecosystem will vary at each …

Melanoma is a fatal skin malignant tumor with a poor prognosis. We found that long
noncoding RNA BASP1‐AS1 is essential for the development and prognosis of melanoma …

Lymphangiogenesis is the mechanism by which the lymphatic system develops and
expands new vessels facilitating fluid drainage and immune cell trafficking. Models to study …

Sphingolipid metabolism is tightly controlled by enzymes to regulate essential processes in
human physiology. The central metabolite is ceramide, a pro‐apoptotic lipid catabolized by …

Notch is a well-conserved signaling pathway all through evolution that is crucial to specify
different cell fates. Although there is a strong context dependent component in each …

Purpose. To improve immunotherapy efficacy for melanoma, a coexpression network and
key genes of M2 macrophages in melanoma were explored. A prognostic risk assessment …

The incidence of melanoma has increased rapidly over the past few decades, with mortality
accounting for more than 75% of all skin cancers. The high metastatic potential of Melanoma …