The nervous system governs both ontogeny and oncology. Regulating organogenesis
during development, maintaining homeostasis, and promoting plasticity throughout life, the …

The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …

The most frequent adult-type primary CNS tumours are diffuse gliomas, but a large variety of
rarer CNS tumour types exists. The classification of these tumours is increasingly based on …

Glioma contains malignant cells in diverse states. Here, we combine spatial transcriptomics,
spatial proteomics, and computational approaches to define glioma cellular states and …

Experience sculpts brain structure and function. Activity-dependent modulation of the
myelinated infrastructure of the nervous system has emerged as a dimension of adaptive …

The role of the nervous system in the regulation of cancer is increasingly appreciated. In
gliomas, neuronal activity drives tumour progression through paracrine signalling factors …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …

Glioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in
terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients …

Colorectal carcinoma (CRC) represents the fourth most common cancer worldwide and is
the third most common cause of malignancy-associated mortality. Distant metastases to the …

Background Glioblastoma is the most frequent and a particularly malignant primary brain
tumor with no efficacy-proven standard therapy for recurrence. It has recently been …