MSC based therapies—new perspectives for the injured lung

J Behnke, S Kremer, T Shahzad, CM Chao… - Journal of clinical …, 2020 - mdpi.com
Chronic lung diseases pose a tremendous global burden. At least one in four people suffer
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …

Mesenchymal stromal cells for acute respiratory distress syndrome (ARDS), sepsis, and COVID-19 infection: optimizing the therapeutic potential

E Gorman, J Millar, D McAuley… - Expert review of …, 2021 - Taylor & Francis
Introduction: Mesenchymal stromal (stem) cell (MSC) therapies are emerging as a promising
therapeutic intervention in patients with Acute Respiratory Distress Syndrome (ARDS) and …

Bone marrow mesenchymal stem cell-derived exosomes attenuate LPS-induced ARDS by modulating macrophage polarization through inhibiting glycolysis in …

H Deng, L Wu, M Liu, L Zhu, Y Chen, H Zhou, X Shi… - Shock, 2020 - journals.lww.com
Macrophages play a key role in the development of sepsis-induced acute respiratory
distress syndrome (ARDS). Recent evidence has proved that glycolysis plays an important …

Microfluidic tools for enhanced characterization of therapeutic stem cells and prediction of their potential antimicrobial secretome

P Marrazzo, V Pizzuti, S Zia, A Sargenti, D Gazzola… - Antibiotics, 2021 - mdpi.com
Antibiotic resistance is creating enormous attention on the development of new antibiotic-
free therapy strategies for bacterial diseases. Mesenchymal stromal stem cells (MSCs) are …

Repair of acute respiratory distress syndrome in COVID-19 by stromal cells (REALIST-COVID Trial): a multicenter, randomized, controlled clinical trial

EA Gorman, J Rynne, HJ Gardiner… - American journal of …, 2023 - atsjournals.org
Rationale: Mesenchymal stromal cells (MSCs) may modulate inflammation, promoting repair
in coronavirus disease (COVID-19)–related acute respiratory distress syndrome (ARDS) …

Mesenchymal stem cell-based therapy as a new therapeutic approach for acute inflammation

K Abdolmohammadi, T Mahmoudi, M Alimohammadi… - Life Sciences, 2023 - Elsevier
Acute inflammatory diseases such as acute colitis, kidney injury, liver failure, lung injury,
myocardial infarction, pancreatitis, septic shock, and spinal cord injury are significant causes …

Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: a phase 1 trial

E Gorman, M Shankar-Hari, P Hopkins… - …, 2021 - thelancet.com
Abstract Background Mesenchymal stromal cells (MSCs) may be of benefit in acute
respiratory distress syndrome (ARDS) due to immunomodulatory, reparative, and …

[HTML][HTML] Stem cell therapy in COVID-19: Pooled evidence from SARS-CoV-2, SARS-CoV, MERS-CoV and ARDS: A systematic review

S Mahendiratta, S Bansal, P Sarma, H Kumar… - Biomedicine & …, 2021 - Elsevier
Abstract Background SARS-CoV-2, which majorly affects the lungs and respiratory tract is
thought due to dysregulation of the immune system which causes an immense imbalance of …

[HTML][HTML] Mesenchymal stem cells as living anti-inflammatory therapy for COVID-19 related acute respiratory distress syndrome

F Lin, TE Ichim, S Pingle, LD Jones… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19), a pandemic disease caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV2), is growing at an exponential rate …

Nebulised mesenchymal stem cell derived extracellular vesicles ameliorate E. coli induced pneumonia in a rodent model

H Gonzalez, S McCarthy, C Masterson… - Stem Cell Research & …, 2023 - Springer
Background Mesenchymal stem cell (MSC) derived extracellular vesicles (EVs) have been
proposed as an alternative to cell therapy, creating new possible delivery modalities such as …