Chemotherapy is widely recognized as an effective approach for treating cancer due to its
ability to eliminate cancer cells using chemotherapeutic drugs. However, traditional …

Cucurbit [n] uril (CB [n]) macrocycles (especially CB [5] to CB [8]) have shown exceptional
attributes since their discovery in 2000. Their stability, water solubility, responsiveness to …

Calixarenes (CAs), representing the third generation of supramolecular hosts and one of the
most widely studied macrocyclic scaffolds, offer (almost) unlimited structure and application …

Conspectus Macrocyclic receptors can serve as alternatives to natural recognition systems
as recognition tools. They provide effectively preorganized cavities to encapsulate guests …

Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Classic prodrug strategies rely on covalent modification of active drugs to provide systems
with superior pharmacokinetic properties than the parent drug and facilitate administration …

This year marks the 50th anniversary of Charles Pedersen's discovery of crown ethers, what
is widely considered the birth of supramolecular chemistry. Since then, the field has …

Cyclodextrins, since their discovery in the late 19th century, were mainly regarded as
excipients. Nevertheless, developments in cyclodextrin research have shown that some of …

Conspectus This Account focuses on stimuli responsive systems that function in aqueous
solution using examples drawn from the work of the Isaacs group using cucurbit [n] uril (CB …

Cyclodextrins are cyclic oligomers of glucose that can form water-soluble inclusion
complexes with small molecules and portions of large compounds. These biocompatible …