Tumor-associated O-glycans of MUC1: Carriers of the glyco-code and targets for cancer vaccine design

DM Beckwith, M Cudic - Seminars in immunology, 2020 - Elsevier
The transformation from normal to malignant phenotype in human cancers is associated with
aberrant cell-surface glycosylation. It has frequently been reported that MUC1, the heavily …

Virus‐like particles for vaccination against cancer

MO Mohsen, DE Speiser, A Knuth… - Wiley Interdisciplinary …, 2020 - Wiley Online Library
Active immunotherapy of cancer aims to treat the disease by inducing effective cellular and
humoral immune responses. Virus‐like particle‐based vaccines have evolved dramatically …

Membrane‐Fusion‐Mediated Multiplex Engineering of Tumor Cell Surface Glycans for Enhanced NK Cell Therapy

C Zheng, Q Zhong, W Song, K Yi, H Kong… - Advanced …, 2023 - Wiley Online Library
Natural killer (NK) cell therapies show potential for tumor treatment but are immunologically
resisted by the overexpressed immunosuppressing tumor cell surface glycans. To reverse …

Recent advance in tumor-associated carbohydrate antigens (TACAs)-based antitumor vaccines

D Feng, AS Shaikh, F Wang - ACS chemical biology, 2016 - ACS Publications
Cancer cells can be distinguished from normal cells by displaying aberrant levels and types
of carbohydrate structures on their surfaces. These carbohydrate structures are known as …

[HTML][HTML] Tumor diagnosis using carbon-based quantum dots: Detection based on the hallmarks of cancer

H Wang, S Yang, L Chen, Y Li, P He, G Wang, H Dong… - Bioactive Materials, 2024 - Elsevier
Carbon-based quantum dots (CQDs) have been shown to have promising application value
in tumor diagnosis. Their use, however, is severely hindered by the complicated nature of …

[HTML][HTML] Recent advances and future perspectives on carbohydrate-based cancer vaccines and therapeutics

C Sorieul, F Papi, F Carboni, S Pecetta… - Pharmacology & …, 2022 - Elsevier
Carbohydrates are abundantly expressed on the surface of both eukaryotic and prokaryotic
cells, often as post translational modifications of proteins. Glycoproteins are recognized by …

Breast cancer immunotherapy: an update

I Makhoul, M Atiq, A Alwbari… - Breast cancer: basic …, 2018 - journals.sagepub.com
The immune system plays a major role in cancer surveillance. Harnessing its power to treat
many cancers is now a reality that has led to cures in hopeless situations where no other …

Insights into the role of sialylation in cancer metastasis, immunity, and therapeutic opportunity

J Huang, J Huang, G Zhang - Cancers, 2022 - mdpi.com
Simple Summary Sialylation is the synthetic process of sialoglycans, which are important in
tumor transformation, proliferation, metastasis, and immune evasion. The primary subjects of …

Carbohydrate‐based vaccines for oncotherapy

MM Wei, YS Wang, XS Ye - Medicinal Research Reviews, 2018 - Wiley Online Library
Cancer is still one of the most serious threats to human worldwide. Aberrant patterns of
glycosylation on the surface of cancer cells, which are correlated with various cancer …

The sweet side of immune evasion: role of glycans in the mechanisms of cancer progression

AFFR Nardy, L Freire-de-Lima… - Frontiers in …, 2016 - frontiersin.org
Glycans are part of the essential components of a cell. These compounds play a
fundamental role in several physiopathological processes, including cell differentiation …