Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

The secretome is defined as the set of molecules and biological factors that are secreted by
cells into the extracellular space. In the past decade, secretome-based therapies have …

Arachidonic acid (ARA, 20: 4 n-6) is an n-6 polyunsaturated 20-carbon fatty acid formed by
the biosynthesis from linoleic acid (LA, 18: 2 n-6). This review considers the essential role …

This review describes the role of bone cells and their surrounding matrix in maintaining
bone strength through the process of bone remodeling. Subsequently, this work focusses on …

The human skeleton is a miracle of engineering, combining both toughness and light weight.
It does so because bones possess cellular mechanisms wherein external mechanical loads …

Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to
prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit …

This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …

The capacity of bone tissue to alter its mass and structure in response to mechanical
demands has long been recognized but the cellular mechanisms involved remained poorly …

Bone is a complex highly structured mechanically active 3D tissue composed of cellular and
matrix elements. The true biological environment of a bone cell is thus derived from a …

Bones are able to withstand functional loads without either breaking or sustaining extensive
damage because they have evolved the capacity to adapt their architecture in relation to …