The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …

Current evidence indicates that coronary microcirculation is a key target for protecting
against cardiac ischemia–reperfusion (I/R) injury. Mitochondrial calcium uniporter (MCU) …

Mitochondrial diseases are one of the largest groups of neurological genetic disorders.
Despite continuous efforts of the scientific community, no cure has been developed, and …

Mitochondria are cellular organelles which generate adenosine triphosphate (ATP)
molecules for the maintenance of cellular energy through the oxidative phosphorylation …

Mitochondria are responsible for ATP production but are also known as regulators of cell
death, and mitochondrial matrix Ca2+ is a key modulator of both ATP production and cell …

OPA1 and MICU1 are both involved in the regulation of mitochondrial Ca 2+ uptake and the
stabilization of the cristae junction, which separates the inner mitochondrial membrane into …

MicroRNAs (miRNAs) are epigenetic regulators that can target and inhibit translation of
multiple mRNAs within a given cell type. As such, a number of different pathways and …

Mitochondrial Ca 2+ uptake has long been considered crucial for meeting the fluctuating
energy demands of cells in the heart and other tissues. Increases in mitochondrial matrix [Ca …

Mitochondria are the key organelles that supply cellular energy. As the most active organ in
the body, the energy required to maintain the mechanical function of the heart requires a …