The colonic epithelium has both absorptive and secretory functions. The transport is
characterized by a net absorption of NaCl, short-chain fatty acids (SCFA), and water …

▪ Abstract The sodium/hydrogen exchange (NHE) gene family plays an integral role in
neutral sodium absorption in the mammalian intestine. The NHE gene family is comprised of …

Biochemical and pharmacological data support the existence of multiple forms of the Na/H
exchanger (NHE). Two isoforms, termed NHE-1 and NHE-2, have recently been isolated …

This review describes recent progress concerning the molecular aspects of the Na+/H+
exchanger. The Na+/H+ exchanger is an important regulator for intracellular pH, cell volume …

We previously cloned, sequenced, and expressed two distinct mammalian Na+/H+
exchanger isoforms (NHE-1 and NHE-2). We report here the cloning of a composite cDNA …

NHE3 is the brush-border (BB) Na+/H+ exchanger of small intestine, colon, and renal
proximal tubule which is involved in large amounts of neutral Na+ absorption. NHE3 is a …

The diuretic drug amiloride and its 5-amino substitute N5-methyl-N5-propylamiloride (MPA)
are potent inhibitors of the growth factor-activatable Na+/H+ exchanger isoform 1 (NHE1) …

A cDNA encoding a new isoform of the rat Na/H exchanger (NHE) family has been identified
by cross-hybridization with an NHE-1 cDNA probe. The 3.9-kilobase stomach cDNA …

The influence of lipophilicity on the conjunctival penetration of beta blockers in the
pigmented rabbit was investigated and compared with that on corneal penetration. The beta …

In this study, the presence of a bicarbonate gradient-dependent, carrier-mediated anion
exchange process for butyrate (a representative short-chain fatty acid) uptake in apical …