Initial research on vitamin E and cancer has focused on α-tocopherol (αT), but recent clinical
studies on cancer-preventive effects of αT supplementation have shown disappointing …

Dclk1-expressing tuft cells constitute a unique intestinal epithelial lineage that is distinct from
enterocytes, Paneth cells, goblet cells, and enteroendocrine cells. Tuft cells express taste …

Rationale: Dysregulation of arachidonic acid (ARA) metabolism results in inflammation;
however, its role in acute lung injury (ALI) remains elusive. In this study, we addressed the …

We designed and synthesised novel quinazolinone tethered phenyl urea derivatives (6a–p)
that triple target the double mutant EGFRL858R/T790M, COX-2, and 15-LOX. Compounds …

The intestinal epithelium plays crucial roles in maintaining gut homeostasis. A key function
consists in constituting a physical and chemical barrier between self and non-self …

Two new series of pyrrolizine-5-carboxamides were synthesized and evaluated for their
anticancer and anti-inflammatory activities. The new compounds exhibited potent cytotoxicity …

Therapeutic targeting of RAS-mutated cancers is difficult, whereas prevention or interception
(treatment before or in the presence of preinvasive lesions) preclinically has proven easier …

Abstract PW06 [(E)‐3‐(9‐ethyl‐9H‐carbazol‐3‐yl)‐1‐(2, 5‐dimethoxyphenyl) prop‐2‐en‐1‐
one], a kind of the carbazole derivative containing chalcone moiety, induced cell apoptosis …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic
reaction. Pancreatic stellate cells (PSCs) are the principal effector cells responsible for …

Pancreatic cancer (PC) is an aggressive carcinoma and the fourth cause of cancer deaths in
Western countries. Although surgery is the most effective therapeutic option for PC, the …