[HTML][HTML] Pancreatic cancer: A review of epidemiology, trend, and risk factors

JX Hu, CF Zhao, WB Chen, QC Liu, QW Li… - World journal of …, 2021 - ncbi.nlm.nih.gov
Despite rapid advances in modern medical technology and significant improvements in
survival rates of many cancers, pancreatic cancer is still a highly lethal gastrointestinal …

[HTML][HTML] Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches

M Orth, P Metzger, S Gerum, J Mayerle, G Schneider… - Radiation …, 2019 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …

[HTML][HTML] Effects of hyperglycemia on the progression of tumor diseases

W Li, X Zhang, H Sang, Y Zhou, C Shang… - Journal of Experimental …, 2019 - Springer
Malignant tumors are often multifactorial. Epidemiological studies have shown that
hyperglycemia raises the prevalence and mortality of certain malignancies, like breast, liver …

[HTML][HTML] Mechanisms of obesity-and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review

R Ruze, J Song, X Yin, Y Chen, R Xu… - Signal transduction and …, 2023 - nature.com
Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

[HTML][HTML] Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting

R Pothuraju, S Rachagani, WM Junker… - Journal of Experimental …, 2018 - Springer
Background Pancreatic cancer (PC) is among foremost causes of cancer related deaths
worldwide due to generic symptoms, lack of effective screening strategies and resistance to …

[HTML][HTML] Glucose metabolism in pancreatic cancer

L Yan, P Raj, W Yao, H Ying - Cancers, 2019 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal
cancers, with a five-year survival rate of around 5% to 8%. To date, very few available drugs …

Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment

RA Keogh, AL Haeberle, CJ Langouët-Astrié… - Science …, 2022 - science.org
Diabetic wounds have poor healing outcomes due to the presence of numerous pathogens
and a dysregulated immune response. Group B Streptococcus (GBS) is commonly isolated …

High glucose: an emerging association between diabetes mellitus and cancer progression

S Supabphol, W Seubwai, S Wongkham… - Journal of Molecular …, 2021 - Springer
The association of cancer and diabetes mellitus (DM) has been studied for decades.
Hyperglycemia and the imbalance of hormones are factors that contribute to the molecular …

The intricate relationship between diabetes, obesity and pancreatic cancer

S Paternoster, M Falasca - Biochimica et Biophysica Acta (BBA)-Reviews …, 2020 - Elsevier
Pancreatic cancer is one of the leading determinants of global cancer mortality, and its
incidence is predicted to increase, to become in 2030 the second most common cause of …

[HTML][HTML] FGF21 facilitates autophagy in prostate cancer cells by inhibiting the PI3K–Akt–mTOR signaling pathway

H Dai, W Hu, L Zhang, F Jiang, X Mao, G Yang… - Cell death & …, 2021 - nature.com
Abstract Fibroblast growth factor 21 (FGF21) plays an important role in regulating glucose
and lipid metabolism, but its role in cancer is less well-studied. We aimed to investigate the …