Although prostate cancer is the most common malignancy to affect men in the Western
world, the molecular mechanisms underlying its development and progression remain …

Molecular markers have the potential to serve not only as prognostic factors but may be
targets for new therapeutic strategies and predictors of response in a range of cancers …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

The identification of cell surface antigens is critical to the development of new diagnostic and
therapeutic modalities for the management of prostate cancer. Prostate stem cell antigen …

Prostate stem cell antigen (PSCA) is a recently defined homologue of the Thy-1/Ly-6 family
of glycosylphosphatidylinositol (GPI)-anchored cell surface antigens. PSCA mRNA is …

The tumor suppressor gene PTEN/MMAC-1/TEP-1 (referred to hereafter as PTEN) maps to
chromosome 10q23 and encodes a dual specificity phosphatase. The PTEN protein …

Background: Human prostate cancers are initially androgen dependent but ultimately
become androgen independent. Overexpression of the Her-2-neu receptor tyrosine kinase …

Prognostic factors in organ confined prostate cancer will reflect survival after surgical radical
prostatectomy. Gleason score, tumour volume, surgical margins and Ki-67 index have the …

Prostate cancer often manifests as morphologically distinct tumour foci and is frequently
found adjacent to presumed precursor lesions such as high‐grade prostatic intraepithelial …

Androgens have been shown to modulate the haematopoietic and immune systems and
have been used clinically for stimulating haematopoiesis in bone marrow failure conditions …