The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …

Viruses manipulate cell biology to utilize monocytes/macrophages as vessels for
dissemination, long-term persistence within tissues and virus replication. Viruses enter cells …

Epilepsy is a serious neurological disorder characterized by abnormal, recurrent, and
synchronous discharges in the brain. Long-term recurrent seizure attacks can cause serious …

The pathology in neurodegenerative diseases is often accompanied by inflammation. It is
well-known that many cells within the central nervous system (CNS) also contribute to …

For over 40 years, the National Institute of Neurological Disorders and Stroke/National
Institutes of Health-funded Anticonvulsant Screening Program has provided a preclinical …

Animal models have provided a wealth of information on mechanisms of epileptogenesis
and comorbidogenesis, and have significantly advanced our ability to investigate the …

Seizures are a common presenting symptom during viral infections of the central nervous
system (CNS) and can occur during the initial phase of infection (“early” or acute …

In the central nervous system (CNS), innate immune surveillance is mainly coordinated by
microglia. These CNS resident myeloid cells are assumed to help orchestrate the immune …

Cortical demyelinated lesions are frequent and widespread in chronic multiple sclerosis
(MS) patients, and may contribute to disease progression. Inflammation and related …

Abstract The Epilepsy Therapy Screening Program (ETSP), formerly known as the
Anticonvulsant Screening Program (ASP), has played an important role in the preclinical …