Tryptophan metabolites are known to participate in the regulation of many cells of the
immune system and are involved in various immune-mediated diseases and disorders …

Abstract Background Coronavirus disease 2019 (COVID-19) is accompanied by activated
immune-inflammatory pathways and oxidative stress, which both induce indoleamine-2, 3 …

Progressive multiple sclerosis (MS) is a chronic disease with a unique pattern, which is
histologically classified into the subpial type 3 lesions in the autopsy. The lesion is also …

Tryptophan catabolism through the kynurenine pathway generates a variety of bioactive
metabolites. Physical exercise can modulate kynurenine pathway metabolism in skeletal …

Background There is now evidence that affective disorders including major depressive
disorder (MDD) and bipolar disorder (BD) are mediated by immune-inflammatory and nitro …

Background: Metabolites of tryptophan, produced via the kynurenine pathway (kynurenines),
have been linked to Alzheimer's disease (AD) in small cohorts with conflicting results …

Tryptophan is an essential amino acid with a huge functional versatility, in addition to its
participation in protein synthesis. Because of the complexity of its metabolism, and the …

Oxido-reduction reactions are a fundamental part of the life due to support many vital
biological processes as cellular respiration and glucose oxidation. In the redox reactions …

Over the past years, an increasing amount of evidence has emerged in support of the
kynurenine pathway's (KP) pivotal role in the pathogenesis of several neurodegenerative …

Reaction energetics of the double (2H+/2e−), ie, the first 1H+/1e−(catechol→ phenoxyl
radical) and the second 1H+/1e−(phenoxyl radical→ quinone) free radical scavenging …