Vascular dysfunction in preeclampsia

MA Opichka, MW Rappelt, DD Gutterman, JL Grobe… - Cells, 2021 - mdpi.com
Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

IL-6 and IL-8: an overview of their roles in healthy and pathological pregnancies

A Vilotić, M Nacka-Aleksić, A Pirković… - International journal of …, 2022 - mdpi.com
Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action,
mediating innate and adaptive immunity and multiple physiological processes, including …

The role of immune cells and mediators in preeclampsia

E Deer, O Herrock, N Campbell, D Cornelius… - Nature Reviews …, 2023 - nature.com
Preeclampsia is a hypertensive disorder of major concern in pregnancy than can lead to
intrauterine growth restriction, placental abruption and stillbirth. The pathophysiology of …

Monocytes and macrophages in pregnancy: The good, the bad, and the ugly

H True, M Blanton, S Sureshchandra… - Immunological …, 2022 - Wiley Online Library
A successful human pregnancy requires precisely timed adaptations by the maternal
immune system to support fetal growth while simultaneously protecting mother and fetus …

Improving preeclampsia risk prediction by modeling pregnancy trajectories from routinely collected electronic medical record data

S Li, Z Wang, LA Vieira, AB Zheutlin, B Ru… - npj Digital …, 2022 - nature.com
Preeclampsia is a heterogeneous and complex disease associated with rising morbidity and
mortality in pregnant women and newborns in the US. Early recognition of patients at risk is …

Role of the monocyte–macrophage system in normal pregnancy and preeclampsia

P Vishnyakova, A Elchaninov, T Fatkhudinov… - International journal of …, 2019 - mdpi.com
The proper functioning of the monocyte–macrophage system, an important unit of innate
immunity, ensures the normal course of pregnancy. In this review, we present the current …

[HTML][HTML] Multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesity

S Sureshchandra, BM Doratt, H True, N Mendoza… - Cell reports, 2023 - cell.com
Leukocyte diversity of the first-trimester maternal-fetal interface has been extensively
described; however, the immunological landscape of the term decidua remains poorly …

Maternal microbiome in preeclampsia pathophysiology and implications on offspring health

JA Ishimwe - Physiological reports, 2021 - Wiley Online Library
Preeclampsia is a devastating hypertensive pregnancy disorder that currently affects 2%–
8% of pregnancies worldwide. It is associated with maternal and fetal mortality and morbidity …

Placental galectins are key players in regulating the maternal adaptive immune response

A Balogh, E Toth, R Romero, K Parej, D Csala… - Frontiers in …, 2019 - frontiersin.org
Galectins are potent immunomodulators that regulate maternal immune responses in
pregnancy and prevent the rejection of the semi-allogeneic fetus that also occurs in …

Placental and maternal sFlt1/PlGF expression in gestational diabetes mellitus

AM Nuzzo, D Giuffrida, L Moretti, P Re, G Grassi… - Scientific Reports, 2021 - nature.com
Gestational diabetes mellitus (GDM) and preeclampsia (PE) are both characterized by
endothelial dysfunction and GDM women have higher incidence of PE. The placenta plays a …