[PDF][PDF] Phospholipases A2 from viperidae snake venoms: how do they induce skeletal muscle damage?
B Lomonte, JM Gutiérrez - 2011 - researchgate.net
Abstract Phospholipases A2 (PLA2s) are abundant components in snake venoms, which
play important toxic roles. This review focuses on group II PLA2s endowed with myotoxic …
play important toxic roles. This review focuses on group II PLA2s endowed with myotoxic …
Secreted Phospholipases A2 from Animal Venoms in Pain and Analgesia
Animal venoms comprise a complex mixture of components that affect several biological
systems. Based on the high selectivity for their molecular targets, these components are also …
systems. Based on the high selectivity for their molecular targets, these components are also …
Structural Basis for the Inhibition of a Phospholipase A2-Like Toxin by Caffeic and Aristolochic Acids
One of the main challenges in toxicology today is to develop therapeutic alternatives for the
treatment of snake venom injuries that are not efficiently neutralized by conventional serum …
treatment of snake venom injuries that are not efficiently neutralized by conventional serum …
Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A2-like proteins using functional, structural and bioinformatics approaches
GHM Salvador, FF Cardoso, AA Gomes… - Scientific Reports, 2019 - nature.com
Ophidian accidents are considered an important neglected tropical disease by the World
Health Organization. Particularly in Latin America, Bothrops snakes are responsible for the …
Health Organization. Particularly in Latin America, Bothrops snakes are responsible for the …
[HTML][HTML] Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca2+-binding loop region for the catalytically inactive …
CAH Fernandes, DP Marchi-Salvador… - Journal of structural …, 2010 - Elsevier
Phospholipases A2 (Asp49-PLA2s) are enzymes responsible for cellular membrane
disruption through Ca2+-dependent hydrolysis of phospholipids. A class of these proteins …
disruption through Ca2+-dependent hydrolysis of phospholipids. A class of these proteins …
Structural, functional, and bioinformatics studies reveal a new snake venom homologue phospholipase A2 class
JI dos Santos, M Cintra‐Francischinelli… - Proteins: Structure …, 2011 - Wiley Online Library
Abstract Phospholipases A2 (PLA2s) are enzymes responsible for membrane disruption
through Ca2+‐dependent hydrolysis of phospholipids. Lys49‐PLA2s are well‐characterized …
through Ca2+‐dependent hydrolysis of phospholipids. Lys49‐PLA2s are well‐characterized …
An emergent role for mitochondrial bioenergetics in the action of snake venom toxins on cancer cells
FA Urra, DE Vivas-Ruiz, EF Sanchez… - Frontiers in …, 2022 - frontiersin.org
Beyond the role of mitochondria in apoptosis initiation/execution, some mitochondrial
adaptations support the metastasis and chemoresistance of cancer cells. This highlights …
adaptations support the metastasis and chemoresistance of cancer cells. This highlights …
Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin
GHM Salvador, TR Dreyer… - … Section D: Biological …, 2015 - journals.iucr.org
Local myonecrosis resulting from snakebite envenomation is not efficiently neutralized by
regular antivenom administration. This limitation is considered to be a significant health …
regular antivenom administration. This limitation is considered to be a significant health …
[HTML][HTML] Crystal structure of a phospholipase A2 from Bothrops asper venom: Insights into a new putative “myotoxic cluster”
GHM Salvador, JI Dos Santos, B Lomonte… - Biochimie, 2017 - Elsevier
Snake venoms from the Viperidae and Elapidae families often have several phospholipases
A 2 (PLA 2 s), which may display different functions despite having a similar structural …
A 2 (PLA 2 s), which may display different functions despite having a similar structural …
Localization of Myotoxin I and Myotoxin II from the venom of Bothrops asper in a murine model
S Vargas-Valerio, J Robleto, S Chaves-Araya… - Toxicon, 2021 - Elsevier
Abstract Phospholipases A 2 (PLA 2 s) and PLA 2-like proteins are significant components
of snake venoms. Some of these proteins act as potent toxins causing muscle necrosis …
of snake venoms. Some of these proteins act as potent toxins causing muscle necrosis …