[PDF][PDF] Phospholipases A2 from viperidae snake venoms: how do they induce skeletal muscle damage?

B Lomonte, JM Gutiérrez - 2011 - researchgate.net
Abstract Phospholipases A2 (PLA2s) are abundant components in snake venoms, which
play important toxic roles. This review focuses on group II PLA2s endowed with myotoxic …

Secreted Phospholipases A2 from Animal Venoms in Pain and Analgesia

VO Zambelli, G Picolo, CAH Fernandes, MRM Fontes… - Toxins, 2017 - mdpi.com
Animal venoms comprise a complex mixture of components that affect several biological
systems. Based on the high selectivity for their molecular targets, these components are also …

Structural Basis for the Inhibition of a Phospholipase A2-Like Toxin by Caffeic and Aristolochic Acids

CAH Fernandes, FF Cardoso, WGL Cavalcante… - PLoS …, 2015 - journals.plos.org
One of the main challenges in toxicology today is to develop therapeutic alternatives for the
treatment of snake venom injuries that are not efficiently neutralized by conventional serum …

Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A2-like proteins using functional, structural and bioinformatics approaches

GHM Salvador, FF Cardoso, AA Gomes… - Scientific Reports, 2019 - nature.com
Ophidian accidents are considered an important neglected tropical disease by the World
Health Organization. Particularly in Latin America, Bothrops snakes are responsible for the …

[HTML][HTML] Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca2+-binding loop region for the catalytically inactive …

CAH Fernandes, DP Marchi-Salvador… - Journal of structural …, 2010 - Elsevier
Phospholipases A2 (Asp49-PLA2s) are enzymes responsible for cellular membrane
disruption through Ca2+-dependent hydrolysis of phospholipids. A class of these proteins …

Structural, functional, and bioinformatics studies reveal a new snake venom homologue phospholipase A2 class

JI dos Santos, M Cintra‐Francischinelli… - Proteins: Structure …, 2011 - Wiley Online Library
Abstract Phospholipases A2 (PLA2s) are enzymes responsible for membrane disruption
through Ca2+‐dependent hydrolysis of phospholipids. Lys49‐PLA2s are well‐characterized …

An emergent role for mitochondrial bioenergetics in the action of snake venom toxins on cancer cells

FA Urra, DE Vivas-Ruiz, EF Sanchez… - Frontiers in …, 2022 - frontiersin.org
Beyond the role of mitochondria in apoptosis initiation/execution, some mitochondrial
adaptations support the metastasis and chemoresistance of cancer cells. This highlights …

Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin

GHM Salvador, TR Dreyer… - … Section D: Biological …, 2015 - journals.iucr.org
Local myonecrosis resulting from snakebite envenomation is not efficiently neutralized by
regular antivenom administration. This limitation is considered to be a significant health …

[HTML][HTML] Crystal structure of a phospholipase A2 from Bothrops asper venom: Insights into a new putative “myotoxic cluster”

GHM Salvador, JI Dos Santos, B Lomonte… - Biochimie, 2017 - Elsevier
Snake venoms from the Viperidae and Elapidae families often have several phospholipases
A 2 (PLA 2 s), which may display different functions despite having a similar structural …

Localization of Myotoxin I and Myotoxin II from the venom of Bothrops asper in a murine model

S Vargas-Valerio, J Robleto, S Chaves-Araya… - Toxicon, 2021 - Elsevier
Abstract Phospholipases A 2 (PLA 2 s) and PLA 2-like proteins are significant components
of snake venoms. Some of these proteins act as potent toxins causing muscle necrosis …