The process of poly (ADP-ribosyl) ation and the major enzyme that catalyses this reaction,
poly (ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since …

Cells are exposed to various endogenous and exogenous insults that induce DNA damage,
which, if unrepaired, impairs genome integrity and leads to the development of various …

Hematologic malignancies include various diseases that develop from hematopoietic stem
cells of bone marrow or lymphatic organs. Currently, conventional DNA-damage-based …

Mitochondria, known for more than a century as the energy powerhouse of a cell, represent
key intracellular signaling hub that are emerging as important determinants of several …

Poly (ADP-ribose) polymerase (PARP) inhibitors effectively kill tumours defective in the
BRCA1 or BRCA2 genes through the concept of synthetic lethality. It is suggested that PARP …

Protein poly ADP-ribosylation (PARylation) is a widespread post-translational modification at
DNA lesions, which is catalyzed by poly (ADP-ribose) polymerases (PARPs). This …

BRCA1 and BRCA2 are important for DNA double-strand break repair by homologous
recombination, and mutations in these genes predispose to breast and other cancers. Poly …

Abstract Poly (ADP-ribose) polymerase (PARP1) facilitates DNA repair by binding to DNA
breaks and attracting DNA repair proteins to the site of damage,,. Nevertheless, PARP1 …

Poly (ADP-ribose) polymerase (PARP) inhibitors have shown promising activity in epithelial
ovarian cancers, especially relapsed platinum-sensitive high-grade serous disease …

DNA repair pathways can enable tumour cells to survive DNA damage that is induced by
chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might …