[HTML][HTML] BRCA genes: the role in genome stability, cancer stemness and therapy resistance
I Gorodetska, I Kozeretska, A Dubrovska - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …
regulating genome integrity, cell division and death. The integrity of cellular genome is …
Development of PARP and immune-checkpoint inhibitor combinations
RA Stewart, PG Pilié, TA Yap - Cancer research, 2018 - AACR
PARP inhibitors drive increased DNA damage, particularly in tumors with existing defects in
DNA repair. This damage not only promotes immune priming through a range of molecular …
DNA repair. This damage not only promotes immune priming through a range of molecular …
[HTML][HTML] The firmicutes/bacteroidetes ratio as a risk factor of breast cancer
J An, H Kwon, YJ Kim - Journal of Clinical Medicine, 2023 - mdpi.com
The gut microbiome can reflect the health condition of the entire body. Firmicutes and
Bacteroidetes, the major phyla of the colon, can influence diseases related to obesity which …
Bacteroidetes, the major phyla of the colon, can influence diseases related to obesity which …
Gene therapy: A promising approach for breast cancer treatment
NT Dastjerd, A Valibeik… - Cell biochemistry …, 2022 - Wiley Online Library
Breast cancer (BC) is the most prevalent malignancy and the second leading cause of death
among women worldwide that is caused by numerous genetic and environmental factors …
among women worldwide that is caused by numerous genetic and environmental factors …
Effects of BRCA Germline Mutations on Triple‐Negative Breast Cancer Prognosis
K Pogoda, A Niwińska, E Sarnowska… - Journal of …, 2020 - Wiley Online Library
Germline BRCA1 and BRCA2 mutations confer an increased lifetime risk for breast cancer
and ovarian cancer. Several studies have investigated prognosis among BRCA1/2 mutation …
and ovarian cancer. Several studies have investigated prognosis among BRCA1/2 mutation …
[HTML][HTML] Molecular characteristics of breast tumors in patients screened for germline predisposition from a population-based observational study
DF Nacer, J Vallon-Christersson, N Nordborg… - Genome Medicine, 2023 - Springer
Abstract Background Pathogenic germline variants (PGVs) in certain genes are linked to
higher lifetime risk of developing breast cancer and can influence preventive surgery …
higher lifetime risk of developing breast cancer and can influence preventive surgery …
[HTML][HTML] Multi-gene panel testing increases germline predisposing mutations' detection in a cohort of breast/ovarian cancer patients from Southern Italy
M Nunziato, F Di Maggio, M Pensabene… - Frontiers in …, 2022 - frontiersin.org
Breast cancer is the most common neoplasia in females worldwide, about 10% being
hereditary/familial and due to DNA variants in cancer-predisposing genes, such as the …
hereditary/familial and due to DNA variants in cancer-predisposing genes, such as the …
Association between BRCA mutational status and survival in patients with breast cancer: A systematic review and meta-analysis
M Liu, F Xie, M Liu, Y Zhang, S Wang - Breast Cancer Research and …, 2021 - Springer
Background Studies evaluating role of BRCA mutations on the survival outcomes in breast
cancer (BC) patients have given confounding results and hence, in this meta-analysis, we …
cancer (BC) patients have given confounding results and hence, in this meta-analysis, we …
Racial and ethnic differences in multigene hereditary cancer panel test results for women with breast cancer
To evaluate the racial and ethnic differences in prevalence of germline pathogenic variants
(PVs) and the effect of race and ethnicity on breast cancer (BC) risk among carriers, results …
(PVs) and the effect of race and ethnicity on breast cancer (BC) risk among carriers, results …
[HTML][HTML] Adjuvant chemotherapy in small node-negative triple-negative breast cancer
TG Steenbruggen, E van Werkhoven… - European Journal of …, 2020 - Elsevier
Background Recommendations on adjuvant chemotherapy in pT1N0M0 triple-negative
breast cancer (TNBC) differ among international guidelines owing to lack of randomized trial …
breast cancer (TNBC) differ among international guidelines owing to lack of randomized trial …