[HTML][HTML] BRCA genes: the role in genome stability, cancer stemness and therapy resistance

I Gorodetska, I Kozeretska, A Dubrovska - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …

Development of PARP and immune-checkpoint inhibitor combinations

RA Stewart, PG Pilié, TA Yap - Cancer research, 2018 - AACR
PARP inhibitors drive increased DNA damage, particularly in tumors with existing defects in
DNA repair. This damage not only promotes immune priming through a range of molecular …

[HTML][HTML] The firmicutes/bacteroidetes ratio as a risk factor of breast cancer

J An, H Kwon, YJ Kim - Journal of Clinical Medicine, 2023 - mdpi.com
The gut microbiome can reflect the health condition of the entire body. Firmicutes and
Bacteroidetes, the major phyla of the colon, can influence diseases related to obesity which …

Gene therapy: A promising approach for breast cancer treatment

NT Dastjerd, A Valibeik… - Cell biochemistry …, 2022 - Wiley Online Library
Breast cancer (BC) is the most prevalent malignancy and the second leading cause of death
among women worldwide that is caused by numerous genetic and environmental factors …

Effects of BRCA Germline Mutations on Triple‐Negative Breast Cancer Prognosis

K Pogoda, A Niwińska, E Sarnowska… - Journal of …, 2020 - Wiley Online Library
Germline BRCA1 and BRCA2 mutations confer an increased lifetime risk for breast cancer
and ovarian cancer. Several studies have investigated prognosis among BRCA1/2 mutation …

[HTML][HTML] Molecular characteristics of breast tumors in patients screened for germline predisposition from a population-based observational study

DF Nacer, J Vallon-Christersson, N Nordborg… - Genome Medicine, 2023 - Springer
Abstract Background Pathogenic germline variants (PGVs) in certain genes are linked to
higher lifetime risk of developing breast cancer and can influence preventive surgery …

[HTML][HTML] Multi-gene panel testing increases germline predisposing mutations' detection in a cohort of breast/ovarian cancer patients from Southern Italy

M Nunziato, F Di Maggio, M Pensabene… - Frontiers in …, 2022 - frontiersin.org
Breast cancer is the most common neoplasia in females worldwide, about 10% being
hereditary/familial and due to DNA variants in cancer-predisposing genes, such as the …

Association between BRCA mutational status and survival in patients with breast cancer: A systematic review and meta-analysis

M Liu, F Xie, M Liu, Y Zhang, S Wang - Breast Cancer Research and …, 2021 - Springer
Background Studies evaluating role of BRCA mutations on the survival outcomes in breast
cancer (BC) patients have given confounding results and hence, in this meta-analysis, we …

Racial and ethnic differences in multigene hereditary cancer panel test results for women with breast cancer

S Yadav, H LaDuca, EC Polley, C Hu… - JNCI: Journal of the …, 2021 - academic.oup.com
To evaluate the racial and ethnic differences in prevalence of germline pathogenic variants
(PVs) and the effect of race and ethnicity on breast cancer (BC) risk among carriers, results …

[HTML][HTML] Adjuvant chemotherapy in small node-negative triple-negative breast cancer

TG Steenbruggen, E van Werkhoven… - European Journal of …, 2020 - Elsevier
Background Recommendations on adjuvant chemotherapy in pT1N0M0 triple-negative
breast cancer (TNBC) differ among international guidelines owing to lack of randomized trial …