Erythrocyte metabolism

PN Chatzinikolaou, NV Margaritelis… - Acta …, 2024 - Wiley Online Library
Our aim is to present an updated overview of the erythrocyte metabolism highlighting its
richness and complexity. We have manually collected and connected the available …

Spatiotemporal metabolomic approaches to the cancer-immunity panorama: a methodological perspective

Y Xiao, Y Li, H Zhao - Molecular Cancer, 2024 - Springer
Metabolic reprogramming drives the development of an immunosuppressive tumor
microenvironment (TME) through various pathways, contributing to cancer progression and …

Genetic polymorphisms and expression of Rhesus blood group RHCE are associated with 2, 3-bisphosphoglycerate in humans at high altitude

A D'alessandro, EJ Earley, T Nemkov… - Proceedings of the …, 2024 - National Acad Sciences
Red blood cell (RBC) metabolic reprogramming upon exposure to high altitude contributes
to physiological human adaptations to hypoxia, a multifaceted process critical to health and …

Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes

T Nemkov, D Stephenson, EJ Earley, GR Keele, A Hay… - Cell Metabolism, 2024 - cell.com
Mature red blood cells (RBCs) lack mitochondria and thus exclusively rely on glycolysis to
generate adenosine triphosphate (ATP) during aging in vivo or storage in blood banks …

[HTML][HTML] Internalization of nano-and micro-plastics in human erythrocytes leads to oxidative stress and estrogen receptor-mediated cellular responses

A Remigante, S Spinelli, L Gambardella… - Free Radical Biology …, 2024 - Elsevier
Plastic material versatility has resulted in a substantial increase in its use in several sectors
of our everyday lives. Consequently, concern regarding human exposure to nano-plastics …

Exploring unconventional attributes of red blood cells and their potential applications in biomedicine

AT Anastasiadi, VZ Arvaniti, KE Hudson… - Protein & …, 2024 - academic.oup.com
Eukaryotic cells are defined as cells containing distinct nuclei and other membranous
organelles. However, red blood cells (RBCs) lack a nucleus and organelles—perhaps to …

Alteration in the number, morphology, function, and metabolism of erythrocytes in high-altitude polycythemia

S Yu, Y Ye, T Wuren, H Yi - Frontiers in Physiology, 2024 - frontiersin.org
Introduction: High-altitude polycythemia (HAPC) is a common chronic high-altitude disease
characterized by significantly increased erythrocyte, hemoglobin (Hb), and hematocrit …

[HTML][HTML] Interplay Between Metabolic Pathways and Increased Oxidative Stress in Human Red Blood Cells

S Spinelli, A Marino, R Morabito, A Remigante - Cells, 2024 - pmc.ncbi.nlm.nih.gov
Red blood cells (RBCs) are highly specialized cells with a limited metabolic repertoire.
However, it has been demonstrated that metabolic processes are affected by the production …

Modeling Red Blood Cell Metabolism in the Omics Era

A Key, Z Haiman, BO Palsson, A D'Alessandro - Metabolites, 2023 - mdpi.com
Red blood cells (RBCs) are abundant (more than 80% of the total cells in the human body),
yet relatively simple, as they lack nuclei and organelles, including mitochondria. Since the …

Ferroptosis regulates hemolysis in stored murine and human red blood cells

A D'Alessandro, GR Keele, AM Hay, T Nemkov… - Blood …, 2024 - ashpublications.org
Red blood cell (RBC) metabolism regulates hemolysis during aging in vivo and in the blood
bank. However, the genetic underpinnings of RBC metabolic heterogeneity and …