[HTML][HTML] Role of red blood cells in clinically relevant bleeding tendencies and complications

R Lassila, JW Weisel - Journal of Thrombosis and Haemostasis, 2023 - Elsevier
The multiple roles of red blood cells (RBCs) are often neglected as contributors in
hemostasis and thrombosis. Proactive opportunities to increase RBC numbers, either …

[HTML][HTML] Fibrinolysis: an illustrated review

RA Risman, NC Kirby, BE Bannish, NE Hudson… - Research and Practice …, 2023 - Elsevier
In response to vessel injury (or other pathological conditions), the hemostatic process is
activated, resulting in a fibrous, cellular-rich structure commonly referred to as a blood clot …

Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage

G Bao, Q Gao, M Cau, N Ali-Mohamad… - Nature …, 2022 - nature.com
Non-compressible hemorrhage is an unmet clinical challenge that accounts for high
mortality in trauma. Rapid pressurized blood flows under hemorrhage impair the function …

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance

S Staessens, F Denorme, O Francois… - …, 2019 - pmc.ncbi.nlm.nih.gov
Ischemic stroke is caused by a thromboembolic occlusion of cerebral arteries. Treatment is
focused on fast and efficient removal of the occluding thrombus, either via intravenous …

[HTML][HTML] Blood clot contraction: mechanisms, pathophysiology, and disease

RI Litvinov, JW Weisel - Research and Practice in Thrombosis and …, 2023 - Elsevier
A State of the Art lecture titled “Blood Clot Contraction: Mechanisms, Pathophysiology, and
Disease” was presented at the International Society on Thrombosis and Haemostasis (ISTH) …

Altered platelet and coagulation function in moderate-to-severe COVID-19

RI Litvinov, NG Evtugina, AD Peshkova, SI Safiullina… - Scientific reports, 2021 - nature.com
To reveal if coagulopathies relate to the course of COVID-19, we examined 255 patients with
moderate and severe COVID-19, receiving anticoagulants and immunosuppressive drugs …

Mechanical behavior of in vitro blood clots and the implications for acute ischemic stroke treatment

S Johnson, J Chueh, MJ Gounis, R McCarthy… - Journal of …, 2020 - jnis.bmj.com
Background Clot mechanical properties are influenced by composition and the arrangement
of components within the clot. This work investigates the effects of platelet-driven contraction …

[HTML][HTML] Pathologically stiff erythrocytes impede contraction of blood clots

V Tutwiler, RI Litvinov, A Protopopova… - Journal of Thrombosis …, 2021 - Elsevier
Background Blood clot contraction, volume shrinkage of the clot, is driven by platelet
contraction and accompanied by compaction of the erythrocytes and their gradual shape …

A whole blood thrombus mimic: constitutive behavior under simple shear

GP Sugerman, S Kakaletsis, P Thakkar… - journal of the …, 2021 - Elsevier
Deep vein thrombosis and pulmonary embolism affect 300,000–600,000 patients each year
in the US. To better understand the highly mechanical pathophysiology of pulmonary …

Immunothrombosis and vascular heterogeneity in cerebral cavernous malformation

MA Globisch, FC Onyeogaziri… - Blood, The Journal …, 2022 - ashpublications.org
Cerebral cavernous malformation (CCM) is a neurovascular disease that results in various
neurological symptoms. Thrombi have been reported in surgically resected CCM patient …