[HTML][HTML] The molecular basis of drug addiction: linking epigenetic to synaptic and circuit mechanisms
EJ Nestler, C Lüscher - Neuron, 2019 - cell.com
Addiction is a disease in which, after a period of recreational use, a subset of individuals
develops compulsive use that does not stop even in light of major negative consequences …
develops compulsive use that does not stop even in light of major negative consequences …
Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens
AK Zinsmaier, Y Dong, YH Huang - Molecular psychiatry, 2022 - nature.com
Cocaine craving, seeking, and relapse are mediated, in part, by cocaine-induced adaptive
changes in the brain reward circuits. The nucleus accumbens (NAc) integrates and …
changes in the brain reward circuits. The nucleus accumbens (NAc) integrates and …
Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core
AC Bobadilla, E Dereschewitz, L Vaccaro… - Molecular …, 2020 - nature.com
Poorly regulated reward seeking is a central feature of substance use disorder. Recent
research shows that rewarding drug-related experiences induce synchronous activation of a …
research shows that rewarding drug-related experiences induce synchronous activation of a …
A competitive model for striatal action selection
The direct and indirect pathway striatal medium spiny neurons (dMSNs and iMSNs) have
long been linked to action selection, but the precise roles of these neurons in this process …
long been linked to action selection, but the precise roles of these neurons in this process …
Advancing the preclinical study of comorbid neuroHIV and substance use disorders: Current perspectives and future directions
Human immunodeficiency virus (HIV) remains a persistent public health concern throughout
the world. Substance use disorders (SUDs) are a common comorbidity that can worsen …
the world. Substance use disorders (SUDs) are a common comorbidity that can worsen …
[HTML][HTML] Cannabidiol treatment might promote resilience to cocaine and methamphetamine use disorders: a review of possible mechanisms
C Calpe-López, MP García-Pardo, MA Aguilar - Molecules, 2019 - mdpi.com
Currently, there are no approved pharmacotherapies for addiction to cocaine and other
psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a …
psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a …
Circuit selectivity in drug versus natural reward seeking behaviors
Substance use disorder (SUD) is characterized, in part by behavior biased toward drug use
and away from natural sources of reward (eg, social interaction, food, sex). The …
and away from natural sources of reward (eg, social interaction, food, sex). The …
The mesolimbic dopamine activity signatures of relapse to alcohol-seeking
The mesolimbic dopamine system comprises distinct compartments supporting different
functions in learning and motivation. Less well understood is how complex addiction-related …
functions in learning and motivation. Less well understood is how complex addiction-related …
Heroin cue–evoked astrocytic structural plasticity at nucleus accumbens synapses inhibits heroin seeking
Background Opioid addiction is a critical medical and societal problem characterized by
vulnerability to relapse. Glutamatergic synapses in the nucleus accumbens regulate the …
vulnerability to relapse. Glutamatergic synapses in the nucleus accumbens regulate the …
OPRM1 A118G Polymorphisms and Its Role in Opioid Addiction: Implication on Severity and Treatment Approaches
The epidemic of opioid addiction is shaping up as the most serious clinical issues of current
times. Opioids have the greatest propensity to develop addiction after first exposure …
times. Opioids have the greatest propensity to develop addiction after first exposure …