Systematic review and meta‐analysis of breastfeeding and later overweight or obesity expands on previous study for World Health Organization

BL Horta, N Rollins, MS Dias, V Garcez… - Acta …, 2023 - Wiley Online Library
Aim To update a systematic review and meta‐analysis of the association of breastfeeding
with overweight or obesity that had been commissioned by the World Health Organization …

FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms

SK Azzam, H Alsafar, AA Sajini - International journal of molecular …, 2022 - mdpi.com
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …

Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm

J Wei, F Liu, Z Lu, Q Fei, Y Ai, PC He, H Shi, X Cui… - Molecular cell, 2018 - cell.com
FTO, the first RNA demethylase discovered, mediates the demethylation of internal N 6-
methyladenosine (m 6 A) and N 6, 2-O-dimethyladenosine (m 6 A m) at the+ 1 position from …

Brain insulin resistance at the crossroads of metabolic and cognitive disorders in humans

S Kullmann, M Heni, M Hallschmid… - Physiological …, 2016 - journals.physiology.org
Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

[HTML][HTML] Ghrelin

TD Müller, R Nogueiras, ML Andermann… - Molecular …, 2015 - Elsevier
Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

FTO–a common genetic basis for obesity and cancer

N Lan, Y Lu, Y Zhang, S Pu, H Xi, X Nie, J Liu… - Frontiers in …, 2020 - frontiersin.org
In recent years, the prevalence of obesity and cancer have been rising. Since this poses a
serious threat to human health, the relationship between the two has attracted much …

The bigger picture of FTO—the first GWAS-identified obesity gene

RJF Loos, GSH Yeo - Nature Reviews Endocrinology, 2014 - nature.com
Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and
obesity associated (FTO) gene are associated obesity traits in genome-wide association …

[HTML][HTML] The hunger genes: pathways to obesity

AA Van der Klaauw, IS Farooqi - Cell, 2015 - cell.com
The global rise in the prevalence of obesity and associated co-morbidities such as type 2
diabetes, cardiovascular disease, and cancer represents a major public health concern. The …

Acute and chronic effects of exercise on appetite, energy intake, and appetite-related hormones: the modulating effect of adiposity, sex, and habitual physical activity

J Dorling, DR Broom, SF Burns, DJ Clayton… - Nutrients, 2018 - mdpi.com
Exercise facilitates weight control, partly through effects on appetite regulation. Single bouts
of exercise induce a short-term energy deficit without stimulating compensatory effects on …

Tracking of obesity-related behaviours from childhood to adulthood: a systematic review

AM Craigie, AA Lake, SA Kelly, AJ Adamson… - Maturitas, 2011 - Elsevier
Obesity in childhood carries a wide range of physical, psychological and social disbenefits
and also increases the risk of adult obesity with its well-recognised, enhanced risk of several …