Antimicrobial resistance: the example of Staphylococcus aureus

FD Lowy - The Journal of clinical investigation, 2003 - Am Soc Clin Investig
S. aureus infections in intensive care units in the National Nosocomial Infections
Surveillance System. Data include the total number of infections from 1987 to 1997. Isolates …

Immune evasion by staphylococci

TJ Foster - Nature reviews microbiology, 2005 - nature.com
Staphylococcus aureus can cause superficial skin infections and, occasionally, deep-seated
infections that entail spread through the blood stream. The organism expresses several …

Insights on Evolution of Virulence and Resistance from the Complete Genome Analysis of an Early Methicillin-Resistant Staphylococcus aureus Strain and a Biofilm-Producing …

SR Gill, DE Fouts, GL Archer, EF Mongodin… - Journal of …, 2005 - Am Soc Microbiol
Staphylococcus aureus is an opportunistic pathogen and the major causative agent of
numerous hospital-and community-acquired infections. Staphylococcus epidermidis has …

Molecular Mechanisms of Staphylococcus aureus Iron Acquisition

ND Hammer, EP Skaar - Annual review of microbiology, 2011 - annualreviews.org
The unique redox potential of iron makes it an ideal cofactor in diverse biochemical
reactions. Iron is therefore vital for the growth and proliferation of nearly all organisms …

The enigma of sepsis

NC Riedemann, RF Guo… - The Journal of clinical …, 2003 - Am Soc Clin Investig
Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the
disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving …

Staphylococcus colonization of the skin and antimicrobial peptides

M Otto - Expert review of dermatology, 2010 - Taylor & Francis
Staphylococci are the most abundant skin-colonizing bacteria and the most important
causes of nosocomial infections and community-associated skin infections. Molecular …

From empiricism to rational design: a personal perspective of the evolution of vaccine development

E De Gregorio, R Rappuoli - Nature Reviews Immunology, 2014 - nature.com
Vaccination, which is the most effective medical intervention that has ever been introduced,
originated from the observation that individuals who survived a plague or smallpox would …

Current concepts on the virulence mechanisms of meticillin-resistant Staphylococcus aureus

RR Watkins, MZ David… - Journal of medical …, 2012 - microbiologyresearch.org
Meticillin-resistant Staphylococcus aureus (MRSA) strains are prevalent bacterial pathogens
that cause both health care and community-associated infections. Increasing resistance to …

Fighting bacterial infections—future treatment options

J Fernebro - Drug Resistance Updates, 2011 - Elsevier
This review summarizes ongoing research aimed at finding novel drugs as alternatives to
traditional antibiotics. Anti-virulence approaches, phage therapy and therapeutic antibodies …

Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies

C Giefing, AL Meinke, M Hanner, T Henics… - The Journal of …, 2008 - rupress.org
Pneumococcus is one of the most important human pathogens that causes life-threatening
invasive diseases, especially at the extremities of age. Capsular polysaccharides (CPSs) …