Neuro-toxic and reproductive effects of BPA

A Santoro, R Chianese, J Troisi… - Current …, 2019 - ingentaconnect.com
Background: Bisphenol A (BPA) is one of the highest volume chemicals produced
worldwide. It has recognized activity as an endocrine-disrupting chemical and has …

Neurodevelopmental disorders and environmental toxicants: epigenetics as an underlying mechanism

NQV Tran, K Miyake - International journal of genomics, 2017 - Wiley Online Library
The increasing prevalence of neurodevelopmental disorders, especially autism spectrum
disorders (ASD) and attention deficit hyperactivity disorder (ADHD), calls for more research …

Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

EFSA Panel on Food Contact Materials … - EFSA …, 2023 - Wiley Online Library
In 2015, EFSA established a temporary tolerable daily intake (t‐TDI) for BPA of 4 μg/kg body
weight (bw) per day. In 2016, the European Commission mandated EFSA to re‐evaluate the …

Bisphenol S impairs behaviors through disturbing endoplasmic reticulum function and reducing lipid levels in the brain of zebrafish

W Wang, Z Li, X Zhang, J Zhang… - Environmental Science & …, 2022 - ACS Publications
The number of neurotoxic pollutants is increasing, but their mechanism of action is unclear.
Here, zebrafish were exposed to 0, 1, 10, and 100 μg/L bisphenol S (BPS) for different …

Environmental mechanisms of neurodevelopmental toxicity

KD Rock, HB Patisaul - Current environmental health reports, 2018 - Springer
Abstract Purpose of Review With the incidence of neurodevelopmental disorders on the rise,
it is imperative to identify and understand the mechanisms by which environmental …

Developmental neurotoxicants and the vulnerable male brain: a systematic review of suspected neurotoxicants that disproportionally affect males

J Kern, D Geier, K Homme, P King, G Bjørklund… - Acta neurobiologiae …, 2017 - ane.pl
The prevalence of neurodevelopmental disorders (NDs), including autism spectrum
disorder, attention‑deficit/hyperactivity disorder, tic disorder, obsessive‑compulsive disorder …

The structural reorganization of the prefrontal cortex during adolescence as a framework for vulnerability to the environment

CM Drzewiecki, JM Juraska - Pharmacology Biochemistry and Behavior, 2020 - Elsevier
Adolescence is a time of increased vulnerability to developing substance use disorders. In
part, this may be due to the wide array of neural changes occurring during this time, many of …

Gonadectomy before puberty increases the number of neurons and glia in the medial prefrontal cortex of female, but not male, rats

WA Koss, MM Lloyd, RN Sadowski… - Developmental …, 2015 - Wiley Online Library
The human prefrontal cortex, important for executive functions, loses gray matter throughout
the adolescent period. In rats, our laboratory demonstrated that a loss of neurons between …

Perinatal BPA exposure alters body weight and composition in a dose specific and sex specific manner: The addition of peripubertal exposure exacerbates adverse …

BS Rubin, M Paranjpe, T DaFonte, C Schaeberle… - Reproductive …, 2017 - Elsevier
Body weight (BW) and body composition were examined in CD-1 mice exposed perinatally
or perinatally and peripubertally to 0, 0.25, 2.5, 25, or 250 μg BPA/kg BW/day. Our goal was …

Long-term bisphenol A exposure exacerbates diet-induced prediabetes via TLR4-dependent hypothalamic inflammation

Q Ma, P Deng, M Lin, L Yang, L Li, L Guo… - Journal of Hazardous …, 2021 - Elsevier
Bisphenol A (BPA), an environmental endocrine-disrupting compound, has been revealed
associated with metabolic disorders such as obesity, prediabetes, and type 2 diabetes …