Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

Glioblastoma (GBM) is the most common primary malignant brain tumor, with a universally
poor prognosis. The emergence of molecular biomarkers has had a significant impact on …

Background There is an urgent need for more effective therapies for glioblastoma. Data from
a previous unrandomised phase 2 trial suggested that lomustine-temozolomide plus …

Tumors with histological features of pilocytic astrocytoma (PA), but with increased mitotic
activity and additional high-grade features (particularly microvascular proliferation and …

Both the perivascular niche (PVN) and the integration into multicellular networks by tumor
microtubes (TMs) have been associated with progression and resistance to therapies in …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

Purpose: Oncogenic fusions consisting of fibroblast growth factor receptor (FGFR) and
TACC are present in a subgroup of glioblastoma (GBM) and other human cancers and have …

Context.—The diagnosis and clinical management of patients with diffuse gliomas (DGs)
have evolved rapidly over the past decade with the emergence of molecular biomarkers that …

Epigenetic changes in DNA methylation contribute to the development of many diseases,
including cancer. In glioblastoma multiforme, the most prevalent primary brain cancer and …

Comprehensive analysis of DNA methylation patterns is critical for understanding the
molecular basis of many human diseases. While hundreds of PCR-based DNA methylation …