Antisense techniques have been employed for over 30 years to suppress expression of
target RNAs. Recently, microRNAs (miRNAs) have emerged as a new class of small, non …

Cancer and organ injury—such as that occurring in the perioperative period, including acute
lung injury, myocardial infarction, and acute gut injury—are among the leading causes of …

Thousands of long non-coding RNAs (lncRNAs) have been identified in mammalian cells.
Some have important functions and their dysregulation can contribute to a variety of disease …

DNA strand displacement has been widely used for the design of molecular circuits, motors,
and sensors in cell-free settings. Recently, it has been shown that this technology can also …

We build off the previously described concept of a nanoflare to develop an oligonucleotide
gold nanoparticle conjugate that is capable of both detecting and regulating intracellular …

The potency and specificity of locked nucleic acid (LNA) antisense oligonucleotides was
investigated as a function of length and affinity. The oligonucleotides were designed to …

Attaining sufficient tissue exposure at the site of action to achieve the desired
pharmacodynamic effect on a target is an important determinant for any drug discovery …

Purpose Cataloguing endogenous miRNA targets by inhibiting miRNA function is
fundamental to understanding the biological importance of each miRNA in gene regulatory …

Anti-microRNA oligonucleotides (AMOs) are steric blocking antisense reagents that inhibit
microRNA (miRNA) function by hybridizing and repressing the activity of a mature miRNA …

Here we describe a DNA analog in which the mesyl (methanesulfonyl) phosphoramidate
group is substituted for the natural phosphodiester group at each internucleotidic position …