Macrophages are key cellular components of innate immunity, acting as the first line of
defense against pathogens to modulate homeostatic and inflammatory responses. They …

Nuclear protein prothymosin α (ProTα) is a unique member of damage-associated molecular
patterns (DAMPs)/alarmins. ProTα prevents neuronal necrosis by causing a cell death mode …

Membrane-active peptides (MAPs) have long been thought of as the key to defeating
antimicrobial-resistant microorganisms. Such peptides, however, may not be sufficient …

The fungal cell wall and membrane are the most common targets of antifungal agents, but
the potential of membrane lipid organization in regulating drug-target interactions has yet to …

Phospholipids are an integral part of the cellular membrane structure and can be produced
by a de novo biosynthetic pathway and, alternatively, by the Kennedy pathway. Studies in …

The mechanisms by which micro‐organisms sense and internalize extracellular pH signals
are not completely understood. One example of a known external pH‐sensing process is the …

The synthesis, characterization, and evaluation of antifungal activity of peptides FQ15 and
FG10 will be conducted to address the hypothesis. The hypothesis of this thesis is that a …

Stress tolerance and adaptability to dynamic environments are two things that make a
microbial pathogen especially dangerous in the setting of a human infection. Cryptococcus …

Mammalian cells maintain a distinct disparity in lipid composition between the two leaflets of
the bilayer of the plasma membrane. This compositional asymmetry is most prominent for …