[HTML][HTML] LRRK2 and idiopathic Parkinson's disease
The etiology of idiopathic Parkinson's disease (iPD) is multifactorial, and both genetics and
environmental exposures are risk factors. While mutations in leucine-rich repeat kinase-2 …
environmental exposures are risk factors. While mutations in leucine-rich repeat kinase-2 …
[HTML][HTML] Linking environmental risk factors with epigenetic mechanisms in Parkinson's disease
M Tsalenchuk, SM Gentleman, SJ Marzi - npj Parkinson's Disease, 2023 - nature.com
Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disease, with a
complex risk structure thought to be influenced by interactions between genetic variants and …
complex risk structure thought to be influenced by interactions between genetic variants and …
Anionic nanoplastic contaminants promote Parkinson's disease–associated α-synuclein aggregation
Recent studies have identified increasing levels of nanoplastic pollution in the environment.
Here, we find that anionic nanoplastic contaminants potently precipitate the formation and …
Here, we find that anionic nanoplastic contaminants potently precipitate the formation and …
Six action steps to address global disparities in Parkinson disease: a World Health Organization priority
Importance The Global Burden of Disease study conducted between 1990 and 2016, based
on a global study of 195 countries and territories, identified Parkinson disease (PD) as the …
on a global study of 195 countries and territories, identified Parkinson disease (PD) as the …
[HTML][HTML] Mitochondrial dysfunction in Parkinson's disease: from mechanistic insights to therapy
XY Gao, T Yang, Y Gu, XH Sun - Frontiers in aging neuroscience, 2022 - frontiersin.org
Parkinson's disease (PD) is one of the most common neurodegenerative movement
disorders worldwide. There are currently no cures or preventative treatments for PD …
disorders worldwide. There are currently no cures or preventative treatments for PD …
[HTML][HTML] Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease
AC Müller-Nedebock, MCJ Dekker, MJ Farrer… - npj Parkinson's …, 2023 - nature.com
The biological basis of the neurodegenerative movement disorder, Parkinson's disease
(PD), is still unclear despite it being 'discovered'over 200 years ago in Western Medicine …
(PD), is still unclear despite it being 'discovered'over 200 years ago in Western Medicine …
[HTML][HTML] The heterogeneity of Parkinson's disease
U Wüllner, P Borghammer, C Choe, I Csoti… - Journal of Neural …, 2023 - Springer
The heterogeneity of Parkinson's disease (PD), ie the various clinical phenotypes,
pathological findings, genetic predispositions and probably also the various implicated …
pathological findings, genetic predispositions and probably also the various implicated …
Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products
K Yang, L Zeng, J Zeng, Y Deng, S Wang, H Xu… - Ageing Research …, 2023 - Elsevier
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder of the
central nervous system after Alzheimer's disease. The current understanding of PD focuses …
central nervous system after Alzheimer's disease. The current understanding of PD focuses …
[HTML][HTML] PARK7/DJ-1 in microglia: implications in Parkinson's disease and relevance as a therapeutic target
F Lind-Holm Mogensen, A Scafidi, A Poli… - Journal of …, 2023 - Springer
Microglia are the immune effector cells of the brain playing critical roles in immune
surveillance and neuroprotection in healthy conditions, while they can sustain …
surveillance and neuroprotection in healthy conditions, while they can sustain …
[HTML][HTML] Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy
AD Van Laar, KR Webb, MT Keeney… - npj Parkinson's …, 2023 - nature.com
Individuals with Parkinson's disease (PD) typically receive a diagnosis once they have
developed motor symptoms, at which point there is already significant loss of substantia …
developed motor symptoms, at which point there is already significant loss of substantia …