Mucins: the frontline defence of the lung

C Ridley, DJ Thornton - Biochemical Society Transactions, 2018 - portlandpress.com
Mucus plays a vital role in protecting the lungs from environmental factors, but conversely, in
muco-obstructive airway disease, mucus becomes pathologic. In its protective role, mucus …

Mucin-bacterial interactions in the human oral cavity and digestive tract

M Derrien, MWJ van Passel… - Gut …, 2010 - Taylor & Francis
Mucins are a family of heavily glycosylated proteins that are the major organic components
of the mucus layer, the protective layer covering the epithelial cells in many human and …

# COVIDisAirborne: AI-enabled multiscale computational microscopy of delta SARS-CoV-2 in a respiratory aerosol

A Dommer, L Casalino, F Kearns… - … journal of high …, 2023 - journals.sagepub.com
We seek to completely revise current models of airborne transmission of respiratory viruses
by providing never-before-seen atomic-level views of the SARS-CoV-2 virus within a …

Structural analysis of N-and O-glycans released from glycoproteins

PH Jensen, NG Karlsson, D Kolarich, NH Packer - Nature protocols, 2012 - nature.com
This protocol shows how to obtain a detailed glycan compositional and structural profile from
purified glycoproteins or protein mixtures, and it can be used to distinguish different isobaric …

Human body fluid proteome analysis

S Hu, JA Loo, DT Wong - Proteomics, 2006 - Wiley Online Library
The focus of this article is to review the recent advances in proteome analysis of human
body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar …

The interaction of the gut microbiota with the mucus barrier in health and disease in human

AP Corfield - Microorganisms, 2018 - mdpi.com
Glycoproteins are major players in the mucus protective barrier in the gastrointestinal and
other mucosal surfaces. In particular the mucus glycoproteins, or mucins, are responsible for …

Mucin‐type O‐glycosylation–putting the pieces together

PH Jensen, D Kolarich, NH Packer - The FEBS journal, 2010 - Wiley Online Library
The O‐glycosylation of Ser and Thr by N‐acetylgalactosamine‐linked (mucin‐type)
oligosaccharides is often overlooked in protein analysis. Three characteristics make O …

A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn

JM Holmén Larsson, H Karlsson, H Sjövall… - …, 2009 - academic.oup.com
High-sensitivity glycan profiling providing detailed structural information is very important in
the search for glycan disease markers. By combining a straight-forward and fast preparation …

Mucin O-glycans suppress quorum-sensing pathways and genetic transformation in Streptococcus mutans

CA Werlang, WG Chen, K Aoki, KM Wheeler… - Nature …, 2021 - nature.com
Mucus barriers accommodate trillions of microorganisms throughout the human body while
preventing pathogenic colonization. In the oral cavity, saliva containing the mucins MUC5B …

Saliva proteome research: current status and future outlook

BL Schulz, J Cooper-White… - Critical reviews in …, 2013 - Taylor & Francis
Human saliva harbours proteins of clinical relevance and about 30% of blood proteins are
also present in saliva. This highlights that saliva can be used for clinical applications just as …