[HTML][HTML] Kisspeptins and the neuroendocrine control of reproduction: Recent progress and new frontiers in kisspeptin research

V Sobrino, MS Avendano, C Perdices-Lopez… - Frontiers in …, 2022 - Elsevier
In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

[HTML][HTML] Carbamate pesticides: shedding light on their impact on the male reproductive system

S Moreira, R Silva, DF Carrageta, MG Alves… - International Journal of …, 2022 - mdpi.com
Carbamates are widely used and known around the world as pesticides in spite of also
having medical applications. This class of chemicals is classified as acetylcholinesterase …

[HTML][HTML] Sexual dimorphism in kisspeptin signaling

EB Lee, I Dilower, CA Marsh, MW Wolfe, S Masumi… - Cells, 2022 - mdpi.com
Kisspeptin (KP) and kisspeptin receptor (KPR) are essential for the onset of puberty,
development of gonads, and maintenance of gonadal function in both males and females …

Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset

X Shi, Y Zhuang, Z Chen, M Xu, J Kuang, XL Sun… - Science …, 2022 - science.org
The neuroendocrine system consists of a heterogeneous collection of neuropeptidergic
neurons in the brain, among which hypothalamic KNDy neurons represent an indispensable …

Hypothalamic overexpression of makorin ring finger protein 3 results in delayed puberty in female mice

SA Roberts, L Naulé, S Chouman, T Johnson… - …, 2022 - academic.oup.com
Makorin ring finger protein 3 (MKRN3) is an important neuroendocrine player in the control
of pubertal timing and upstream inhibitor of gonadotropin-releasing hormone secretion. In …

[HTML][HTML] Transcriptional profiling of Kiss1 neurons from arcuate and rostral periventricular hypothalamic regions in female mice

S Manchishi, M Prater, WH Colledge - Reproduction, 2024 - rep.bioscientifica.com
In brief The transcriptional profiles of Kiss1 neurons from the arcuate and the rostral
periventricular region of the third ventricle of the hypothalamus have been directly compared …

Inactivating NHLH2 variants cause idiopathic hypogonadotropic hypogonadism and obesity in humans

AK Topaloglu, E Simsek, MA Kocher, J Mammadova… - Human genetics, 2022 - Springer
Metabolism has a role in determining the time of pubertal development and fertility.
Nonetheless, molecular/cellular pathways linking metabolism/body weight to …

Agouti‐related peptide neuronal silencing overcomes delayed puberty in neonatally underfed male mice

C Decourt, GADP Connolly, C Ancel… - Journal of …, 2022 - Wiley Online Library
Agouti‐related peptide (AgRP) neurons are thought to indirectly regulate the activity of
hypothalamic gonadotrophin‐releasing hormone neurons which control fertility. AgRP …

[HTML][HTML] DNA Methylation in INA, NHLH2, and THBS4 Is Associated with Metastatic Disease in Renal Cell Carcinoma

O Katzendorn, I Peters, N Dubrowinskaja, JM Moog… - Cancers, 2021 - mdpi.com
Simple Summary Early prediction of aggressive cancer using biomarkers is thought to be
important for future improvements in the personalized treatment of renal cell carcinoma …

[HTML][HTML] In Silico Examination of Single Nucleotide Missense Mutations in NHLH2, a Gene Linked to Infertility and Obesity

AT Madsen, DJ Good - International Journal of Molecular Sciences, 2023 - mdpi.com
Continual advances in our understanding of the human genome have led to exponential
increases in known single nucleotide variants. The characterization of each of the variants …