The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than
the central nervous system (CNS). One reason for this difference is the difference in glial cell …

Although much is known about the regenerative capacity of retinal ganglion cells, very
significant barriers remain in our ability to restore visual function following traumatic injury or …

Axon regeneration is essential to restore the nervous system after axon injury. However, the
neuronal cell biology that underlies axon regeneration is incompletely understood. Here we …

The ability of injured axons to regenerate declines with age, yet the mechanisms that
regulate axon regeneration in response to age are not known. Here we show that axon …

Mitochondrial defects are tightly linked to axon degeneration, yet the underlying cellular
mechanisms remain poorly understood. In Caenorhabditis elegans, PVQ axons that lack …

Axonal regrowth is crucial for recovery from CNS injury but is severely restricted in adult
mammals. We used a genome-wide loss-of-function screen for factors limiting axonal …

Neurodegeneration has been correlated with mitochondrial DNA (mtDNA) damage and
exposure to environmental toxins, but causation is unclear. We investigated the ability of …

Animals generate a wide range of highly coordinated motor outputs, which allows them to
execute purposeful behaviors. Individual neurons in the circuits that generate behaviors …

Growth and destruction are central components of the neuronal injury response. Injured
axons that are capable of repair, including axons in the mammalian peripheral nervous …

Growth cones facilitate the repair of nervous system damage by providing the driving force
for axon regeneration. Using single-neuron laser axotomy and in vivo time-lapse imaging …