Extracting biological information with computational analysis of Fourier-transform infrared (FTIR) biospectroscopy datasets: current practices to future perspectives

J Trevisan, PP Angelov, PL Carmichael, AD Scott… - Analyst, 2012 - pubs.rsc.org
Applying Fourier-transform infrared (FTIR) spectroscopy (or related technologies such as
Raman spectroscopy) to biological questions (defined as biospectroscopy) is relatively …

Biospectroscopy to metabolically profile biomolecular structure: a multistage approach linking computational analysis with biomarkers

JG Kelly, J Trevisan, AD Scott… - Journal of proteome …, 2011 - ACS Publications
Biospectroscopy is employed to derive absorbance spectra representative of biomolecules
present in biological samples. The mid-infrared region (λ= 2.5 μm− 25 μm) is absorbed to …

Using Fourier transform IR spectroscopy to analyze biological materials

MJ Baker, J Trevisan, P Bassan, R Bhargava… - Nature protocols, 2014 - nature.com
IR spectroscopy is an excellent method for biological analyses. It enables the
nonperturbative, label-free extraction of biochemical information and images toward …

Distinguishing cell types or populations based on the computational analysis of their infrared spectra

FL Martin, JG Kelly, V Llabjani, PL Martin-Hirsch… - Nature protocols, 2010 - nature.com
Infrared (IR) spectroscopy of intact cells results in a fingerprint of their biochemistry in the
form of an IR spectrum; this has given rise to the new field of biospectroscopy. This protocol …

Resonant Mie scattering (RMieS) correction of infrared spectra from highly scattering biological samples

P Bassan, A Kohler, H Martens, J Lee, HJ Byrne… - Analyst, 2010 - pubs.rsc.org
Infrared spectra of single biological cells often exhibit the 'dispersion artefact'observed as a
sharp decrease in intensity on the high wavenumber side of absorption bands, in particular …

Diagnosis of tumors during tissue-conserving surgery with integrated autofluorescence and Raman scattering microscopy

K Kong, CJ Rowlands, S Varma… - Proceedings of the …, 2013 - National Acad Sciences
Tissue-conserving surgery is used increasingly in cancer treatment. However, one of the
main challenges in this type of surgery is the detection of tumor margins. Histopathology …

Resonant Mie scattering in infrared spectroscopy of biological materials–understanding the 'dispersion artefact'

P Bassan, HJ Byrne, F Bonnier, J Lee, P Dumas… - Analyst, 2009 - pubs.rsc.org
Infrared spectroscopic cytology is potentially a powerful clinical tool. However, in order for it
to be successful, practitioners must be able to extract reliably a pure absorption spectrum …

Breast cancer detection by ATR-FTIR spectroscopy of blood serum and multivariate data-analysis

VE Sitnikova, MA Kotkova, TN Nosenko, TN Kotkova… - Talanta, 2020 - Elsevier
Detection of breast cancer has particular importance for the diagnosis of cancer diseases.
This is the most common type of cancer among women. Breast cancer is a malignant tumor …

Understanding the molecular information contained in principal component analysis of vibrational spectra of biological systems

F Bonnier, HJ Byrne - Analyst, 2012 - pubs.rsc.org
K-means clustering followed by Principal Component Analysis (PCA) is employed to
analyse Raman spectroscopic maps of single biological cells. K-means clustering …

Diagnostic segregation of human brain tumours using Fourier-transform infrared and/or Raman spectroscopy coupled with discriminant analysis

K Gajjar, LD Heppenstall, W Pang, KM Ashton… - Analytical …, 2013 - pubs.rsc.org
The most common initial treatment received by patients with a brain tumour is surgical
removal of the growth. Precise histopathological diagnosis of brain tumours is to some …