Presence of benzimidazole nucleus in numerous categories of therapeutic agents such as
antimicrobials, antivirals, antiparasites, anticancer, anti-inflammatory, antioxidants, proton …

Great advances in elucidating molecular structures allow the precise determination of the
interactions between a protein and a therapeutic agent. Enzyme inhibitors are used as a …

Inhibition of angiogenesis through inhibition of vascular endothelial growth factor receptor 2
(VEGFR-2) has been applied in cancer therapy because of its important role in promoting …

The kinase/endonuclease inositol requiring enzyme 1 (IRE1α), one of the sensors of
unfolded protein accumulation in the endoplasmic reticulum that triggers the unfolded …

The chemoselective and complementary Pd-and Cu-catalyzed N-arylation of 2-
aminobenzimidazoles is described. Selective N-arylation of the amino-group was achieved …

A series of new 5-(arylidene/heteroarylidene)-2-(morpholinoimino)-3-phenylthiazolidin-4-
ones (3–30) was synthesized. Cytotoxic effectiveness of these products was done against …

We report a novel VEGFR-2 inhibitor, developed by the back-to-front approach. Docking
experiments indicated that the 3-chloromethylphenylurea motif of the lead compound …

A complementary set of Ni-and Cu-based catalyst systems for the selective N-arylation of 2-
aminobenzimidazoles have been developed. Selective N-arylation of the primary amine (C …

A copper (II)‐catalyzed selective C NH2 arylation of 2‐aminobenzimidazoles and related C‐
amino‐NH‐azoles was achieved in presence of 2, 2′‐bipyridine and cesium carbonate at …

Two series of chalcone and thiopyrimidine benzofuran derivatives were designed,
synthesized and evaluated in vitro for their vascular endothelial growth factor receptor …