Methods from artificial intelligence (AI) trained on large datasets of sequences and
structures can now" write" proteins with new shapes and molecular functions de novo …

G protein-coupled receptors (GPCRs) are prominent drug targets responsible for
extracellular-to-intracellular signal transduction. GPCRs can form functional dimers that …

While the existence and functional role of class C G-protein-coupled receptors (GPCR)
dimers is well established, there is still a lack of consensus regarding class A and B GPCR …

G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing
signals from the extracellular environment to the inside of the cell. They mediate the effects …

That signaling bias is a nth level of complexity in the understanding of G protein-coupled
receptor (GPCR) activation is a first fact. That its exhaustive description, including the mode …

Heterozygous autosomal dominant mutations in the CXCR4 gene cause WHIM syndrome, a
severe combined immunodeficiency disorder. The mutations primarily affect the C-terminal …

Abstract Objectives Jian-Pi-Yin decoction (JPY), a prescription derived from the traditional
Chinese medicine Shen-Ling-Bai-Zhu-San, has shown good clinical efficacy in the treatment …

The chemokine receptor CXCR4 is involved in the development and migration of stem and
immune cells but is also implicated in tumor progression and metastasis for a variety of …

Cancer remains a leading cause of mortality worldwide and calls for novel therapeutic
targets. Membrane proteins are key players in various cancer types but present unique …

The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor (GPCR) and a key
regulator of appetite and metabolism. It can interact with the melanocortin-receptor …