Lipofuscin accumulates with age as intracellular fluorescent granules originating from
incomplete lysosomal digestion of phagocytosed and autophagocytosed material. The …

The eye is an ideal organ for imaging by a multi-photon excitation approach, because ocular
tissues such as the sclera, cornea, lens and neurosensory retina, are highly transparent to …

Although imaging of the living retina with adaptive optics scanning light ophthalmoscopy
(AOSLO) provides microscopic access to individual cells, such as photoreceptors, retinal …

Background Noninvasive assessment of metabolic processes that sustain regeneration of
human retinal visual pigments (visual cycle) is essential to improve ophthalmic diagnostics …

High resolution multiphoton tomography and fluorescence lifetime imaging differentiates
glioma from adjacent brain in native tissue samples ex vivo. Presently, multiphoton …

Handbook of Visual Optics offers an authoritative overview of encyclopedic knowledge in the
field of physiological optics. It builds from fundamental concepts to the science and …

High-resolution imaging techniques capable of detecting identifiable endogenous
fluorophores in the eye along with genetic testing will dramatically improve diagnostic …

The purpose of this report is to summarize the current strengths and weaknesses of the non-
human primate (NHP) experimental glaucoma (EG) model through sections devoted to its …

Visual transduction is the process in the eye whereby absorption of light in the retina is
translated into electrical signals that ultimately reach the brain. The first challenge presented …

Purpose: Although extrinsic fluorophores can be introduced to label specific cell types in the
retina, endogenous fluorophores, such as NAD (P) H, FAD, collagen, and others, are …