Tyrosine hydroxylase is the rate-limiting enzyme of catecholamine biosynthesis; it uses
tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino terminal …

Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …

Lysine acetylation is a reversible posttranslational modification of proteins and plays a key
role in regulating gene expression. Technological limitations have so far prevented a global …

AMPK is a highly conserved sensor of cellular energy status that is activated under
conditions of low intracellular ATP. AMPK responds to energy stress by suppressing cell …

Dynamic networks of protein–protein interactions regulate numerous cellular processes and
determine the ability to respond appropriately to environmental stimuli. However, the …

The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all
eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of …

Summary mTORC1 is a signal integrator and master regulator of cellular anabolic processes
linked to cell growth and survival. Here, we demonstrate that mTORC1 promotes lipid …

Proteins participate in complex sets of interactions that represent the mechanistic foundation
for much of the physiology and function of the cell. These protein–protein interactions are …

This chapter includes a historic overview of 14-3-3 proteins with an emphasis on the
differences between potentially cancer-relevant isoforms on the genomic, protein and …

The highly conserved and ubiquitously expressed 14‐3‐3 proteins regulate differentiation,
cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in …