This perspective is partly review and partly proposal. N-degrons and C-degrons are
degradation signals whose main determinants are, respectively, the N-terminal and C …

The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …

The 26S proteasome is a 2.5-MDa complex responsible for the selective, ATP-dependent
degradation of ubiquitylated proteins in eukaryotic cells. Substrates in hundreds cellular …

Abstract p97 (also known as valosin-containing protein (VCP) in mammals or Cdc48p in
Saccharomyces cerevisiae) is an evolutionarily conserved ATPase present in all eukaryotes …

Ubiquitin-binding domain (UBD) proteins regulate numerous cellular processes, but their
specificities toward ubiquitin chain types in cells remain obscure. Here, we perform a …

Valosin‐containing protein (VCP) is an evolutionarily conserved ubiquitin‐dependent ATP
ase that mediates the degradation of proteins through the ubiquitin–proteasome pathway …

Cdc48/p97 is an essential and highly conserved AAA+ ATPase that uses its protein-
unfoldase activity to extract ubiquitinated polypeptides from macromolecular complexes and …

The dynamic composition of proteins associated with nuclear DNA is a fundamental property
of chromosome biology. In the chromatin compartment dedicated protein complexes govern …

Proteolytic machineries containing multisubunit protease complexes and AAA-ATPases play
a key role in protein quality control and the regulation of protein homeostasis. In these …

Adenosine triphosphatases (ATPases) associated with a variety of cellular activities (AAA+),
the hexameric ring-shaped motor complexes located in all ATP-driven proteolytic machines …