[HTML][HTML] P53 mutations in colorectal cancer-molecular pathogenesis and pharmacological reactivation

XL Li, J Zhou, ZR Chen, WJ Chng - World journal of …, 2015 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most common malignancies with high prevalence and
low 5-year survival. CRC is a heterogeneous disease with a complex, genetic and …

Biomarker-guided targeted and immunotherapies in malignant pleural mesothelioma

H Yang, D Xu, RA Schmid… - Therapeutic advances in …, 2020 - journals.sagepub.com
Malignant pleural mesothelioma (MPM) is a lethal thoracic malignancy whose incidence is
still increasing worldwide. MPM is characterized by frequent inactivation of tumor …

[HTML][HTML] Targeted next-generation sequencing of cancer genes in advanced stage malignant pleural mesothelioma: a retrospective study

ML Iacono, V Monica, L Righi, F Grosso… - Journal of thoracic …, 2015 - Elsevier
Introduction Malignant pleural mesothelioma (MPM) is a rare malignant disease, and the
understanding of molecular pathogenesis has lagged behind other malignancies. Methods …

A p53‐dependent tumor suppressor network is induced by selective miR‐125a‐5p inhibition in multiple myeloma cells

M Leotta, L Biamonte, L Raimondi… - Journal of cellular …, 2014 - Wiley Online Library
The analysis of deregulated microRNAs (miRNAs) is emerging as a novel approach to
disclose the regulation of tumor suppressor or tumor promoting pathways in tumor cells …

The Oncolytic Virus dl922-947 Triggers Immunogenic Cell Death in Mesothelioma and Reduces Xenograft Growth

S Di Somma, CA Iannuzzi, C Passaro, IM Forte… - Frontiers in …, 2019 - frontiersin.org
Background: Malignant pleural mesothelioma (MPM) is an aggressive cancer associated
with asbestos exposure that urgently requires effective therapeutic strategies. Current …

P53-regulated miR-320a targets PDL1 and is downregulated in malignant mesothelioma

C Costa, P Indovina, E Mattioli, IM Forte… - Cell Death & …, 2020 - nature.com
Malignant pleural mesothelioma (MPM) is an aggressive cancer, related to asbestos
exposure, which has a dismal prognosis. MPM diagnosis is late and often challenging …

MicroRNA-215-5p treatment suppresses mesothelioma progression via the MDM2-p53-signaling axis

A Singh, N Bhattacharyya, A Srivastava, N Pruett… - Molecular Therapy, 2019 - cell.com
Malignant pleural mesothelioma (MPM) is an incurable, aggressive neoplasm with
distinctive features, including preservation of wild-type p53, irrespective of histologic …

[HTML][HTML] Capsaicin Exerts Antitumor Activity in Mesothelioma Cells

E Andretta, A Costa, E Ventura, M Quintiliani… - Nutrients, 2024 - mdpi.com
Background/Objectives: Mesothelioma is an aggressive cancer with limited treatment
options. Mesothelioma therapy often involves a multimodal approach including surgery …

[HTML][HTML] UHRF1 is a novel druggable epigenetic target in malignant pleural mesothelioma

ES Reardon, V Shukla, S Xi, SK Gara, Y Liu… - Journal of Thoracic …, 2021 - Elsevier
Introduction Ubiquitin-like with plant homeodomain and ring finger domains 1 (UHRF1)
encodes a master regulator of DNA methylation that has emerged as an epigenetic driver in …

Antitumoral potential, antioxidant activity and carotenoid content of two Southern Italy tomato cultivars extracts: San Marzano and Corbarino

D Barone, L Cito, G Tommonaro… - Journal of cellular …, 2018 - Wiley Online Library
Gastric cancer represents a diffuse and aggressive neoplasm, whose mortality index is
among the highest in the world. Predisposing factors are E‐cadherin mutations …