OSCA/TMEM63s form mechanically activated (MA) ion channels in plants and animals,
respectively. OSCAs and related TMEM16s and transmembrane channel-like (TMC) …

Ion channels play important roles in fundamental biological processes, such as electric
signaling in cells, muscle contraction, hormone secretion, and regulation of the immune …

TWIK-related acid-sensitive K+ (TASK) channels, including TASK-1, TASK-3, and TASK-5,
are important members of the two-pore domain potassium (K2P) channel family. TASK-5 is …

The hydrophobic gating model, in which ion permeation is inhibited by the hydrophobicity,
rather than a physical occlusion of the nanopore, functions in various ion channels including …

Cell membranes are highly intricate systems comprising numerous lipid species and
membrane proteins, where channel proteins, lipid molecules, and lipid bilayers, as …

Potassium channels of the Two-Pore Domain (K2P) subfamily, KCNK1-KCNK18, play
crucial roles in controlling the electrical activity of many different cell types and represent …

Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and
thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of …

Highly selective for K+ at neutral pH, the TWIK1 channel becomes permeable to Na+ upon
acidification. Using molecular dynamics simulations, we identify a network of residues …

TWIK1 is a widely expressed pH-gated two-pore domain K+ channel (K2P) that contributes
to cardiac rhythm generation, as well as insulin release from pancreatic beta cells. TWIK1 …

Every voltage-gated ion channel (VGIC) has a pore domain (PD) made from four subunits,
each comprising an antiparallel transmembrane helix pair bridged by a loop. The extent to …