The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Nonalcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver disease that is not
from excess alcohol consumption, but is often associated with obesity, type 2 diabetes, and …

Adiponectin is an adipocytokine that was recently shown to be anti‐fibrogenic in hepatic
fibrosis. Leptin, on the other hand, promotes hepatic fibrosis. The purpose of the present …

Elucidation of the causes of inflammation has vital importance in the development of new
approaches for the treatment of arthritic diseases. The degradation of aggrecan by …

Nonalcoholic steatohepatitis (NASH) is commonly found in patients with obesity and is often
accompanied with abnormally elevated levels of plasma leptin, ie. hyperleptinemia. A …

Obesity and type II diabetes mellitus are often associated with hyperleptinemia and
commonly accompanied by nonalcoholic steatohepatitis, which could cause hepatic fibrosis …

BACKGROUND AND PURPOSE Hyperleptinemia is commonly found in obese patients,
associated with non‐alcoholic steatohepatitis and hepatic fibrosis. Hepatic stellate cells …

Owing to the increased incidence of obesity and its association with heart failure, there is
now great interest in elucidating the underlying molecular mechanisms linking these …

Mammary glands develop postnatally in response to the hypothalamic‐pituitary‐gonadal
axis. Obesity‐induced changes in the local environment, however, retard mammary gland …

Mechanisms by which leptin stimulates collagen α1 (I)[Col1a (I)] gene expression are
unclear. The purposes of this study were to identify the trans-acting factors and cis-acting …