Introduction: Management of antimicrobial resistance in multi-drug-resistant-Klebsiella
pneumoniae (MDR-KP) is a major challenge for clinicians. The optimal treatment option for …

Neurotoxicity is one major unwanted side-effects associated with polymyxin (ie, colistin and
polymyxin B) therapy. Clinically, colistin neurotoxicity is characterized by neurological …

In the last decades, we have witnessed a steady increase in infections caused by multidrug-
resistant (MDR) bacteria. These infections are associated with higher morbidity and …

Infections due to Klebsiella pneumoniae have been increasing in intensive care units (ICUs)
in the last decade. Such infections pose a serious problem, especially when antimicrobial …

Objectives To assess the role that real-time therapeutic drug monitoring (TDM)-guided
optimization of continuous-infusion (CI) meropenem may have in maximizing empirical …

The emergence of antimicrobial resistance in Gram-negative bacteria poses a huge health
challenge. The therapeutic use of polymyxins (ie, colistin and polymyxin B) is commonplace …

Background Bloodstream infections (BSI) are a major complication in the early phase of a
haematopoietic stem cell transplant (HSCT). Aim To describe the incidence and risk factors …

Purpose To investigate the prevalence, risk factors of intestinal carbapenem-resistant
Enterobacteriaceae (CRE) colonization and bloodstream infection (BSI) caused by CRE in …

Severe bacterial infections are a serious problem after cord blood transplantation (CBT).
Colonization with multidrug-resistant Gram-negative rods (MRGNR) is associated with …

ABSTRACT Introduction: Carbapenem-resistant Klebsiella pneumoniae (CR-KP) infections
are associated with high morbidity and mortality rates. A therapeutic approach based on the …