Application of the discrete element method for manufacturing process simulation in the pharmaceutical industry

SB Yeom, ES Ha, MS Kim, SH Jeong, SJ Hwang… - Pharmaceutics, 2019 - mdpi.com
Process simulation using mathematical modeling tools is becoming more common in the
pharmaceutical industry. A mechanistic model is a mathematical modeling tool that can …

Pharmaceutical application of multivariate modelling techniques: a review on the manufacturing of tablets

G Shi, L Lin, Y Liu, G Chen, Y Luo, Y Wu, H Li - RSC advances, 2021 - pubs.rsc.org
The tablet manufacturing process is a complex system, especially in continuous
manufacturing (CM). It includes multiple unit operations, such as mixing, granulation, and …

Bionic stirring device for horizontal composter to improve aeration efficiency: Design and optimisation using discrete and finite element methods

J Wang, C Li, Z Zhu, X Zhu, H Li, SM Nyambura… - … and Electronics in …, 2024 - Elsevier
Effective stirring devices are essential for horizontal composting to enhance food waste
disintegration, but studies on flexible compost stirrers, their fracture risk, and prevention …

Study of the die compaction of powders to high relative densities using the discrete element method

S Garner, J Strong, A Zavaliangos - Powder technology, 2018 - Elsevier
The mechanical behavior of powders during die compaction was investigated using the
discrete element method (DEM), in which powders are modeled as discrete particles with …

Prediction of random packing density and flowability for non-spherical particles by deep convolutional neural networks and Discrete Element Method simulations

R Hesse, F Krull, S Antonyuk - Powder Technology, 2021 - Elsevier
Non-spherical particles can be found in many industrial processes. Unfortunately, scalar
shape parameters are often insufficient to predict their complex behavior. Therefore, this …

RTD-based material tracking in a fully-continuous dry granulation tableting line

MC Martinetz, AP Karttunen, S Sacher, P Wahl… - International journal of …, 2018 - Elsevier
Continuous manufacturing (CM) offers quality and cost-effectiveness benefits over currently
dominating batch processing. One challenge that needs to be addressed when …

基于颗粒缩放的小麦粉离散元参数标定.

李永祥, 李飞翔, 徐雪萌, 申长璞… - Transactions of the …, 2019 - search.ebscohost.com
为获得小麦粉离散元仿真精确的接触参数, 将不规则形状的小麦粉简化成软质球形颗粒,
利用颗粒接触缩放原理和量纲分析进行颗粒缩放, 将平均粒径0.212 mm 的小麦粉放大至1.2 …

Parameters calibration of discrete element model for corn stalk powder compression simulation

W Weiwei, CAI Danyan, XIE Jinjie, Z Chunling… - Nongye Jixie Xuebao …, 2021 - nyjxxb.net
In order to improve the accuracy of the parameters needed in the discrete element
simulation process of the corn stalk powder, the Hertz-Mindlin with JKR Bonding contact …

Dynamic compaction of cohesive granular materials: scaling behavior and bonding structures

M Sonzogni, JM Vanson, K Ioannidou, Y Reynier… - Soft Matter, 2024 - pubs.rsc.org
The compaction of cohesive granular materials is a common operation in powder-based
manufacture of many products. However, the influence of particle-scale parameters such as …

Application of open source FEM and DEM simulations for dynamic belt deflection modelling

J Shen, C Wheeler, D Ilic, J Chen - Powder Technology, 2019 - Elsevier
Belt deflection due to the belt weight and bulk solid loads is essential not only for reducing
the flexure resistance but also for extending the service life of belt conveyors. Current …